Abstract：
Diabetes has become a critical challenge to the global health concerns. Cytotoxicity and development of resistance against available drugs for management of diabetes have shifted the focus of global scientific researchers from synthetic to herbal medications. Therefore, the current study was conducted to investigate the possible anti-hyperglycemic potential of Dryopteris stewartii using Swiss albino mice. To evaluate any possible toxic effect of the plant, acute oral toxicity test was performed while the anti-diabetic effects of aqueous and ethanol extracts at 500 mg/kg, positive, negative and normal control were assessed simultaneously. The anti-diabetic study revealed that aqueous extract has higher anti-diabetic potential than ethanol extract while lowered blood glucose level at second week reaching 150 mg/dL, exerting stronger anti-diabetic effects, compared to ethanol extract (190 mg/dL). Oral glucose tolerance findings revealed that aqueous extract decreased blood glucose level by -0.41-fold, compared to ethanol extract showing a decrease by only -0.29-folds. The histopathological evaluation of liver and pancreas of all groups revealed normal cell architecture with no morphological abnormalities. These results suggested the possible use of D. stewartii as anti-diabetic herbal drug in near future. However, these recommendations are conditioned by deep mechanistic studies.
摘要：
糖尿病已成为全球健康问题的关键挑战。细胞毒性和对治疗糖尿病可用药物的耐药性的发展已经将全球科学研究人员的焦点从合成药物转移到草药药物。因此,本研究的目的是利用瑞士白化小鼠,研究黑鳞翅目动物可能的抗高血糖潜能.为了评估植物的任何可能的毒性作用，急性口服毒性试验，而500毫克/千克的水和乙醇提取物的抗糖尿病作用，积极的,同时评估阴性和正常对照。抗糖尿病研究表明，水提取物比乙醇提取物具有更高的抗糖尿病潜力，同时在第二周降低血糖水平达到150mg/dL，发挥更强的抗糖尿病作用，与乙醇提取物（190mg/dL）相比。口服葡萄糖耐量结果显示，水提取物使血糖水平降低-0.41倍，与乙醇提取物相比，仅减少了-0.29倍。所有组的肝脏和胰腺的组织病理学评估显示正常的细胞结构，没有形态学异常。这些结果表明在不久的将来可能使用D.stewartii作为抗糖尿病草药。然而,这些建议受到深入机理研究的制约。
