Abstract：
OBJECTIVE: To explore whether vitamin D receptor (VDR) gene polymorphisms are associated to the risk of chronic and aggressive periodontitis in the Chinese population.
METHODS: The electronic databases PubMed, SCOPUS, Web of Science, China Biology Medicine Database, and China National Knowledge Infrastructure Database were searched without language restrictions to find available publications about the association between BsmI, TaqI, FokI, and ApaI polymorphisms of VDR gene and the risk of periodontitis listed up to December 2021. The Newcastle-Ottawa scale (NOS) was used to assess the quality of eligible publications and those with a score of ≥ 6 were considered to be of high quality. The strength of associations was evaluated using the odds ratio (OR) and 95% confidence intervals (CI).
RESULTS: 16 eligible studies including 6106 participants were finally selected for pooled analyses. The NOS score of eligible papers ranged from 6 to 8, showing that all analyzed studies were of high quality. VDR BsmI polymorphism under the allele (OR = 1.46, 95% CI: 1.1-1.9, P = 0.008) and dominant (OR = 1.5, 95% CI: 1.06-2.12, P = 0.022) models was significantly associated with the risk of severe periodontitis in South China. VDR FokI polymorphism under the allele (OR = 2.01, 95% CI: 1.3-2.9, P < 0.001), dominant (OR = 2.2, 95% CI: 1.14-4.23, P = 0.018), and recessive (OR = 2.9, 95% CI: 1.5-5.5, P = 0.001) models showed a significant association with the risk of aggressive periodontitis in whole Chinese population. There was a protective effect of the ApaI polymorphism against the development of severe periodontitis in the North Chinese people; indeed, a significant negative association was found between ApaI polymorphism under the dominant model and the risk of severe periodontitis in North China (OR = 0.41, 95% CI: 019-087, P = 0.021). However, VDR TaqI polymorphism showed no significant association.
CONCLUSIONS: The present meta-analysis detected a significant association between BsmI, FokI, and ApaI polymorphisms in the VDR gene and the risk of severe periodontitis in China.
METHODS: The electronic databases PubMed, SCOPUS, Web of Science, China Biology Medicine Database, and China National Knowledge Infrastructure Database were searched without language restrictions to find available publications about the association between BsmI, TaqI, FokI, and ApaI polymorphisms of VDR gene and the risk of periodontitis listed up to December 2021. The Newcastle-Ottawa scale (NOS) was used to assess the quality of eligible publications and those with a score of ≥ 6 were considered to be of high quality. The strength of associations was evaluated using the odds ratio (OR) and 95% confidence intervals (CI).
RESULTS: 16 eligible studies including 6106 participants were finally selected for pooled analyses. The NOS score of eligible papers ranged from 6 to 8, showing that all analyzed studies were of high quality. VDR BsmI polymorphism under the allele (OR = 1.46, 95% CI: 1.1-1.9, P = 0.008) and dominant (OR = 1.5, 95% CI: 1.06-2.12, P = 0.022) models was significantly associated with the risk of severe periodontitis in South China. VDR FokI polymorphism under the allele (OR = 2.01, 95% CI: 1.3-2.9, P < 0.001), dominant (OR = 2.2, 95% CI: 1.14-4.23, P = 0.018), and recessive (OR = 2.9, 95% CI: 1.5-5.5, P = 0.001) models showed a significant association with the risk of aggressive periodontitis in whole Chinese population. There was a protective effect of the ApaI polymorphism against the development of severe periodontitis in the North Chinese people; indeed, a significant negative association was found between ApaI polymorphism under the dominant model and the risk of severe periodontitis in North China (OR = 0.41, 95% CI: 019-087, P = 0.021). However, VDR TaqI polymorphism showed no significant association.
CONCLUSIONS: The present meta-analysis detected a significant association between BsmI, FokI, and ApaI polymorphisms in the VDR gene and the risk of severe periodontitis in China.
摘要：
目的：探讨维生素D受体（VDR）基因多态性与中国人群慢性侵袭性牙周炎发病风险的关系。
方法：电子数据库PubMed，Scopus,WebofScience,中国生物医学数据库,和中国国家知识基础设施数据库在没有语言限制的情况下进行了搜索，以查找有关BsmI之间关联的可用出版物，TaqI,FokI,截至2021年12月，VDR基因ApaI多态性与牙周炎风险。纽卡斯尔-渥太华量表（NOS）用于评估合格出版物的质量，得分≥6的出版物被认为是高质量的。使用比值比（OR）和95％置信区间（CI）评估关联强度。
结果：最终选择了包括6106名参与者在内的16项符合条件的研究进行汇总分析。合格论文的NOS得分在6到8之间，表明所有分析的研究都是高质量的。等位基因(OR=1.46,95%CI:1.1-1.9,P=0.008)和显性(OR=1.5,95%CI:1.06-2.12,P=0.022)模式下的VDRBsmI多态性与中国南方地区重度牙周炎风险显著相关。等位基因下VDRFokI多态性(OR=2.01,95%CI:1.3-2.9,P<0.001),显性（OR=2.2，95%CI：1.14-4.23，P=0.018），和隐性（OR=2.9，95％CI：1.5-5.5，P=0.001）模型显示与整个中国人群中侵袭性牙周炎的风险显着相关。ApaI多态性对华北人群严重牙周炎的发展有保护作用；的确，显性模型下ApaI多态性与华北地区重度牙周炎风险呈显著负相关(OR=0.41,95%CI:019-087,P=0.021).然而,TaqI基因VDR多态性无显著相干性。
结论：本荟萃分析检测到BsmI，FokI,和ApaI基因多态性与中国重度牙周炎的风险。
方法：电子数据库PubMed，Scopus,WebofScience,中国生物医学数据库,和中国国家知识基础设施数据库在没有语言限制的情况下进行了搜索，以查找有关BsmI之间关联的可用出版物，TaqI,FokI,截至2021年12月，VDR基因ApaI多态性与牙周炎风险。纽卡斯尔-渥太华量表（NOS）用于评估合格出版物的质量，得分≥6的出版物被认为是高质量的。使用比值比（OR）和95％置信区间（CI）评估关联强度。
结果：最终选择了包括6106名参与者在内的16项符合条件的研究进行汇总分析。合格论文的NOS得分在6到8之间，表明所有分析的研究都是高质量的。等位基因(OR=1.46,95%CI:1.1-1.9,P=0.008)和显性(OR=1.5,95%CI:1.06-2.12,P=0.022)模式下的VDRBsmI多态性与中国南方地区重度牙周炎风险显著相关。等位基因下VDRFokI多态性(OR=2.01,95%CI:1.3-2.9,P<0.001),显性（OR=2.2，95%CI：1.14-4.23，P=0.018），和隐性（OR=2.9，95％CI：1.5-5.5，P=0.001）模型显示与整个中国人群中侵袭性牙周炎的风险显着相关。ApaI多态性对华北人群严重牙周炎的发展有保护作用；的确，显性模型下ApaI多态性与华北地区重度牙周炎风险呈显著负相关(OR=0.41,95%CI:019-087,P=0.021).然而,TaqI基因VDR多态性无显著相干性。
结论：本荟萃分析检测到BsmI，FokI,和ApaI基因多态性与中国重度牙周炎的风险。
