PDF(Pubmed)
Abstract：
UNASSIGNED: Leprosy is primarily a disease of peripheral nerves. Some isolated case reports and case series have communicated imaging changes in the central nervous system (CNS) and brachial plexus in patients with leprosy.
UNASSIGNED: To study the neuroimaging abnormalities in patients with lepra bacilli-positive neuropathy in the context of CNS, spinal root ganglion, and brachial plexus.
UNASSIGNED: Prospective observational study.
UNASSIGNED: We screened newly-diagnosed patients with multibacillary leprosy presenting with neuropathy. Patients with bacilli-positive sural nerve biopsies were included in the study and subjected to magnetic resonance imaging (MRI) of the brain and spinal cord.
UNASSIGNED: A total of 54 patients with bacteriologically confirmed multibacillary leprosy were screened; Mycobacterium leprae was demonstrated in the sural nerve biopsies of 29 patients. Five patients (5/29; 17.24%) had MRI abnormalities in CNS, spinal root ganglion, and/or brachial plexus. Three patients had MRI changes suggestive of either myelitis or ganglionitis. One patient had T2/FLAIR hyperintensity in the middle cerebellar peduncle while 1 had T2/FLAIR hyperintensity in the brachial plexus.
UNASSIGNED: CNS, spinal root ganglion, and brachial plexus are involved in patients with leprous neuropathy. Immunological reaction against M leprae antigen might be a plausible pathogenetic mechanism for brachial plexus and CNS imaging abnormalities.
UNASSIGNED: To study the neuroimaging abnormalities in patients with lepra bacilli-positive neuropathy in the context of CNS, spinal root ganglion, and brachial plexus.
UNASSIGNED: Prospective observational study.
UNASSIGNED: We screened newly-diagnosed patients with multibacillary leprosy presenting with neuropathy. Patients with bacilli-positive sural nerve biopsies were included in the study and subjected to magnetic resonance imaging (MRI) of the brain and spinal cord.
UNASSIGNED: A total of 54 patients with bacteriologically confirmed multibacillary leprosy were screened; Mycobacterium leprae was demonstrated in the sural nerve biopsies of 29 patients. Five patients (5/29; 17.24%) had MRI abnormalities in CNS, spinal root ganglion, and/or brachial plexus. Three patients had MRI changes suggestive of either myelitis or ganglionitis. One patient had T2/FLAIR hyperintensity in the middle cerebellar peduncle while 1 had T2/FLAIR hyperintensity in the brachial plexus.
UNASSIGNED: CNS, spinal root ganglion, and brachial plexus are involved in patients with leprous neuropathy. Immunological reaction against M leprae antigen might be a plausible pathogenetic mechanism for brachial plexus and CNS imaging abnormalities.
摘要：
未经证实：麻风病主要是一种周围神经疾病。一些孤立的病例报告和病例系列已传达了麻风病患者中枢神经系统（CNS）和臂丛神经的影像学变化。
未经授权：为了研究中枢神经系统背景下的lepra杆菌阳性神经病患者的神经影像学异常，脊髓根神经节,和臂丛神经.
未经评估：前瞻性观察性研究。
UASSIGNED：我们筛选了新诊断的多杆菌麻风病伴神经病变患者。将具有杆菌阳性腓肠神经活检的患者纳入研究，并对其进行脑和脊髓的磁共振成像（MRI）。
UNASSIGNED：共筛查了54例经细菌学证实的多杆菌麻风病患者；29例患者的腓肠神经活检证实了麻风分枝杆菌。5例(5/29;17.24%)中枢神经系统MRI异常,脊髓根神经节,和/或臂丛神经。三名患者的MRI改变提示脊髓炎或神经节炎。一名患者在小脑中部有T2/FLAIR高强度，而一名患者在臂丛神经中有T2/FLAIR高强度。
未经评估：CNS，脊髓根神经节,麻风神经病患者与臂丛神经有关。针对麻风M抗原的免疫反应可能是臂丛神经和中枢神经系统影像学异常的合理致病机制。
未经授权：为了研究中枢神经系统背景下的lepra杆菌阳性神经病患者的神经影像学异常，脊髓根神经节,和臂丛神经.
未经评估：前瞻性观察性研究。
UASSIGNED：我们筛选了新诊断的多杆菌麻风病伴神经病变患者。将具有杆菌阳性腓肠神经活检的患者纳入研究，并对其进行脑和脊髓的磁共振成像（MRI）。
UNASSIGNED：共筛查了54例经细菌学证实的多杆菌麻风病患者；29例患者的腓肠神经活检证实了麻风分枝杆菌。5例(5/29;17.24%)中枢神经系统MRI异常,脊髓根神经节,和/或臂丛神经。三名患者的MRI改变提示脊髓炎或神经节炎。一名患者在小脑中部有T2/FLAIR高强度，而一名患者在臂丛神经中有T2/FLAIR高强度。
未经评估：CNS，脊髓根神经节,麻风神经病患者与臂丛神经有关。针对麻风M抗原的免疫反应可能是臂丛神经和中枢神经系统影像学异常的合理致病机制。
