%0 Journal Article
%T Central nervous system, spinal root ganglion and brachial plexus involvement in leprosy: A prospective study.
%A Verma S
%A Garg RK
%A Rizvi I
%A Malhotra HS
%A Kumar N
%A Jain A
%A Suvirya S
%A Parihar A
%A Verma R
%A Sharma PK
%A Pandey S
%A Uniyal R
%A Prakash S
%A Verma S
%A Garg RK
%A Rizvi I
%A Malhotra HS
%A Kumar N
%A Jain A
%A Suvirya S
%A Parihar A
%A Verma R
%A Sharma PK
%A Pandey S
%A Uniyal R
%A Prakash S
%J J Cent Nerv Syst Dis
%V 14
%N 0
%D 2022
%M 36277272
暂无%R 10.1177/11795735221135477
%X <B>UNASSIGNED: </B>Leprosy is primarily a disease of peripheral nerves. Some isolated case reports and case series have communicated imaging changes in the central nervous system (CNS) and brachial plexus in patients with leprosy.<BR><B>UNASSIGNED: </B>To study the neuroimaging abnormalities in patients with lepra bacilli-positive neuropathy in the context of CNS, spinal root ganglion, and brachial plexus.<BR><B>UNASSIGNED: </B>Prospective observational study.<BR><B>UNASSIGNED: </B>We screened newly-diagnosed patients with multibacillary leprosy presenting with neuropathy. Patients with bacilli-positive sural nerve biopsies were included in the study and subjected to magnetic resonance imaging (MRI) of the brain and spinal cord.<BR><B>UNASSIGNED: </B>A total of 54 patients with bacteriologically confirmed multibacillary leprosy were screened; Mycobacterium leprae was demonstrated in the sural nerve biopsies of 29 patients. Five patients (5/29; 17.24%) had MRI abnormalities in CNS, spinal root ganglion, and/or brachial plexus. Three patients had MRI changes suggestive of either myelitis or ganglionitis. One patient had T2/FLAIR hyperintensity in the middle cerebellar peduncle while 1 had T2/FLAIR hyperintensity in the brachial plexus.<BR><B>UNASSIGNED: </B>CNS, spinal root ganglion, and brachial plexus are involved in patients with leprous neuropathy. Immunological reaction against M leprae antigen might be a plausible pathogenetic mechanism for brachial plexus and CNS imaging abnormalities.