{Reference Type}: Journal Article
{Title}: Central nervous system, spinal root ganglion and brachial plexus involvement in leprosy: A prospective study.
{Author}: Verma S;Garg RK;Rizvi I;Malhotra HS;Kumar N;Jain A;Suvirya S;Parihar A;Verma R;Sharma PK;Pandey S;Uniyal R;Prakash S;Verma S;Garg RK;Rizvi I;Malhotra HS;Kumar N;Jain A;Suvirya S;Parihar A;Verma R;Sharma PK;Pandey S;Uniyal R;Prakash S;
{Journal}: J Cent Nerv Syst Dis
{Volume}: 14
{Issue}: 0
{Year}: 2022
暂无{DOI}: 10.1177/11795735221135477
{Abstract}: <B>UNASSIGNED: </B>Leprosy is primarily a disease of peripheral nerves. Some isolated case reports and case series have communicated imaging changes in the central nervous system (CNS) and brachial plexus in patients with leprosy.<BR><B>UNASSIGNED: </B>To study the neuroimaging abnormalities in patients with lepra bacilli-positive neuropathy in the context of CNS, spinal root ganglion, and brachial plexus.<BR><B>UNASSIGNED: </B>Prospective observational study.<BR><B>UNASSIGNED: </B>We screened newly-diagnosed patients with multibacillary leprosy presenting with neuropathy. Patients with bacilli-positive sural nerve biopsies were included in the study and subjected to magnetic resonance imaging (MRI) of the brain and spinal cord.<BR><B>UNASSIGNED: </B>A total of 54 patients with bacteriologically confirmed multibacillary leprosy were screened; Mycobacterium leprae was demonstrated in the sural nerve biopsies of 29 patients. Five patients (5/29; 17.24%) had MRI abnormalities in CNS, spinal root ganglion, and/or brachial plexus. Three patients had MRI changes suggestive of either myelitis or ganglionitis. One patient had T2/FLAIR hyperintensity in the middle cerebellar peduncle while 1 had T2/FLAIR hyperintensity in the brachial plexus.<BR><B>UNASSIGNED: </B>CNS, spinal root ganglion, and brachial plexus are involved in patients with leprous neuropathy. Immunological reaction against M leprae antigen might be a plausible pathogenetic mechanism for brachial plexus and CNS imaging abnormalities.