PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the 2-year effectiveness of reduced-fluence photodynamic therapy (rf-PDT) for chronic central serous chorioretinopathy (cCSC).
UNASSIGNED: Retrospective cohort study.
UNASSIGNED: A total of 223 consecutive patients with newly diagnosed cCSC with active serous retinal detachment (SRD) were included from May 2007 to June 2017 and followed up for at least 2 years. Patients who underwent ocular treatment other than cataract surgery before the beginning of recruitment and those who had macular neovascularization at baseline were excluded.
UNASSIGNED: All patients underwent a comprehensive ophthalmic evaluation, including measurements of best-corrected visual acuity (BCVA), slit-lamp examination, dilated fundus examination, color fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, and spectral-domain OCT. An inverse probability of treatment weighting (IPTW) methodology was applied to balance 18 baseline characteristics between patients who received rf-PDT (rf-PDT group) and those who did not receive treatment (controls). Inverse probability of treatment weighting survival analysis and regression were performed.
UNASSIGNED: The proportion of patients whose BCVA at 24 months was the same or improved compared with the baseline visual acuity (VA) (VA maintenance rate).
UNASSIGNED: A total of 155 eyes (rf-PDT group: 74; controls: 81) were analyzed. The patients\' backgrounds were well balanced after IPTW with standardized differences of < 0.10. An IPTW regression analysis revealed that the VA maintenance rate was significantly higher in the rf-PDT group than in the controls (93.6% vs. 70.9%, P < 0.001, 12 months; 85.7% vs. 69.8%, P = 0.019, 24 months). The rf-PDT group tended to show better VA improvement, but was not statistically significant (-0.06 vs. -0.008, P = 0.07, 12 months; -0.06 vs. -0.03, P = 0.32, 24 months). An IPTW Cox regression showed a significantly higher rate of complete SRD remission in the rf-PDT group (hazard ratio, 5.05; 95% confidence interval, 3.24-7.89; P < 0.001).
UNASSIGNED: The study suggests the beneficial effect of rf-PDT for cCSC for both VA maintenance and higher proportion of complete SRD remission in the clinical setting.
UNASSIGNED: Retrospective cohort study.
UNASSIGNED: A total of 223 consecutive patients with newly diagnosed cCSC with active serous retinal detachment (SRD) were included from May 2007 to June 2017 and followed up for at least 2 years. Patients who underwent ocular treatment other than cataract surgery before the beginning of recruitment and those who had macular neovascularization at baseline were excluded.
UNASSIGNED: All patients underwent a comprehensive ophthalmic evaluation, including measurements of best-corrected visual acuity (BCVA), slit-lamp examination, dilated fundus examination, color fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, and spectral-domain OCT. An inverse probability of treatment weighting (IPTW) methodology was applied to balance 18 baseline characteristics between patients who received rf-PDT (rf-PDT group) and those who did not receive treatment (controls). Inverse probability of treatment weighting survival analysis and regression were performed.
UNASSIGNED: The proportion of patients whose BCVA at 24 months was the same or improved compared with the baseline visual acuity (VA) (VA maintenance rate).
UNASSIGNED: A total of 155 eyes (rf-PDT group: 74; controls: 81) were analyzed. The patients\' backgrounds were well balanced after IPTW with standardized differences of < 0.10. An IPTW regression analysis revealed that the VA maintenance rate was significantly higher in the rf-PDT group than in the controls (93.6% vs. 70.9%, P < 0.001, 12 months; 85.7% vs. 69.8%, P = 0.019, 24 months). The rf-PDT group tended to show better VA improvement, but was not statistically significant (-0.06 vs. -0.008, P = 0.07, 12 months; -0.06 vs. -0.03, P = 0.32, 24 months). An IPTW Cox regression showed a significantly higher rate of complete SRD remission in the rf-PDT group (hazard ratio, 5.05; 95% confidence interval, 3.24-7.89; P < 0.001).
UNASSIGNED: The study suggests the beneficial effect of rf-PDT for cCSC for both VA maintenance and higher proportion of complete SRD remission in the clinical setting.
摘要：
UNASSIGNED：目的研究低通量光动力疗法（rf-PDT）治疗慢性中心性浆液性脉络膜视网膜病变（cCSC）的2年有效性。
未经评估：回顾性队列研究。
UNASSIGNED：从2007年5月至2017年6月，共纳入223例新诊断的cCSC伴活动性浆液性视网膜脱离（SRD）的连续患者，并随访至少2年。除白内障手术外，在招募开始前接受眼部治疗的患者和基线时黄斑新生血管形成的患者被排除在外。
未经评估：所有患者都接受了全面的眼科评估，包括最佳矫正视力（BCVA）的测量，裂隙灯检查,扩张眼底检查，彩色眼底摄影，眼底自发荧光，荧光素血管造影,吲哚菁绿血管造影,和谱域OCT。应用逆概率加权(IPTW)方法来平衡接受rf-PDT(rf-PDT组)的患者和未接受治疗(对照)的患者之间的18个基线特征。进行治疗加权生存的逆概率分析和回归。
UNASSIGNED：与基线视力（VA）相比，24个月时BCVA相同或改善的患者比例（VA维持率）。
未经证实：共分析了155只眼（rf-PDT组：74只；对照：81只）。IPTW后患者的背景平衡良好，标准化差异<0.10。IPTW回归分析显示，rf-PDT组的VA维持率明显高于对照组（93.6％vs.70.9%,P<0.001，12个月；85.7%vs.69.8%,P=0.019，24个月）。rf-PDT组倾向于表现出更好的VA改善，但没有统计学意义(-0.06vs.-0.008，P=0.07，12个月；-0.06vs.-0.03，P=0.32，24个月）。IPTWCox回归显示rf-PDT组SRD完全缓解率显著较高(风险比,5.05；95%置信区间，3.24-7.89；P<0.001）。
UNASSIGNED：该研究表明rf-PDT对cCSC的有益作用，既可以维持VA，也可以提高临床上SRD完全缓解的比例。
未经评估：回顾性队列研究。
UNASSIGNED：从2007年5月至2017年6月，共纳入223例新诊断的cCSC伴活动性浆液性视网膜脱离（SRD）的连续患者，并随访至少2年。除白内障手术外，在招募开始前接受眼部治疗的患者和基线时黄斑新生血管形成的患者被排除在外。
未经评估：所有患者都接受了全面的眼科评估，包括最佳矫正视力（BCVA）的测量，裂隙灯检查,扩张眼底检查，彩色眼底摄影，眼底自发荧光，荧光素血管造影,吲哚菁绿血管造影,和谱域OCT。应用逆概率加权(IPTW)方法来平衡接受rf-PDT(rf-PDT组)的患者和未接受治疗(对照)的患者之间的18个基线特征。进行治疗加权生存的逆概率分析和回归。
UNASSIGNED：与基线视力（VA）相比，24个月时BCVA相同或改善的患者比例（VA维持率）。
未经证实：共分析了155只眼（rf-PDT组：74只；对照：81只）。IPTW后患者的背景平衡良好，标准化差异<0.10。IPTW回归分析显示，rf-PDT组的VA维持率明显高于对照组（93.6％vs.70.9%,P<0.001，12个月；85.7%vs.69.8%,P=0.019，24个月）。rf-PDT组倾向于表现出更好的VA改善，但没有统计学意义(-0.06vs.-0.008，P=0.07，12个月；-0.06vs.-0.03，P=0.32，24个月）。IPTWCox回归显示rf-PDT组SRD完全缓解率显著较高(风险比,5.05；95%置信区间，3.24-7.89；P<0.001）。
UNASSIGNED：该研究表明rf-PDT对cCSC的有益作用，既可以维持VA，也可以提高临床上SRD完全缓解的比例。
