{Reference Type}: Journal Article
{Title}: Effectiveness of Reduced-fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: A Propensity Score Analysis.
{Author}: Aisu N;Miyake M;Hosoda Y;Mori Y;Takahashi A;Muraoka Y;Ueda-Arakawa N;Miyata M;Oishi A;Tamura H;Ooto S;Yamashiro K;Tsujikawa A;Aisu N;Miyake M;Hosoda Y;Mori Y;Takahashi A;Muraoka Y;Ueda-Arakawa N;Miyata M;Oishi A;Tamura H;Ooto S;Yamashiro K;Tsujikawa A;
{Journal}: Ophthalmol Sci
{Volume}: 2
{Issue}: 2
{Year}: Jun 2022
暂无{DOI}: 10.1016/j.xops.2022.100152
{Abstract}: <B>UNASSIGNED: </B>To investigate the 2-year effectiveness of reduced-fluence photodynamic therapy (rf-PDT) for chronic central serous chorioretinopathy (cCSC).<BR><B>UNASSIGNED: </B>Retrospective cohort study.<BR><B>UNASSIGNED: </B>A total of 223 consecutive patients with newly diagnosed cCSC with active serous retinal detachment (SRD) were included from May 2007 to June 2017 and followed up for at least 2 years. Patients who underwent ocular treatment other than cataract surgery before the beginning of recruitment and those who had macular neovascularization at baseline were excluded.<BR><B>UNASSIGNED: </B>All patients underwent a comprehensive ophthalmic evaluation, including measurements of best-corrected visual acuity (BCVA), slit-lamp examination, dilated fundus examination, color fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, and spectral-domain OCT. An inverse probability of treatment weighting (IPTW) methodology was applied to balance 18 baseline characteristics between patients who received rf-PDT (rf-PDT group) and those who did not receive treatment (controls). Inverse probability of treatment weighting survival analysis and regression were performed.<BR><B>UNASSIGNED: </B>The proportion of patients whose BCVA at 24 months was the same or improved compared with the baseline visual acuity (VA) (VA maintenance rate).<BR><B>UNASSIGNED: </B>A total of 155 eyes (rf-PDT group: 74; controls: 81) were analyzed. The patients' backgrounds were well balanced after IPTW with standardized differences of < 0.10. An IPTW regression analysis revealed that the VA maintenance rate was significantly higher in the rf-PDT group than in the controls (93.6% vs. 70.9%, P < 0.001, 12 months; 85.7% vs. 69.8%, P = 0.019, 24 months). The rf-PDT group tended to show better VA improvement, but was not statistically significant (-0.06 vs. -0.008, P = 0.07, 12 months; -0.06 vs. -0.03, P = 0.32, 24 months). An IPTW Cox regression showed a significantly higher rate of complete SRD remission in the rf-PDT group (hazard ratio, 5.05; 95% confidence interval, 3.24-7.89; P < 0.001).<BR><B>UNASSIGNED: </B>The study suggests the beneficial effect of rf-PDT for cCSC for both VA maintenance and higher proportion of complete SRD remission in the clinical setting.