PDF(Pubmed)
Abstract：
Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.
摘要：
感觉异常是自闭症和精神分裂症的特征。在自闭症中，感觉神经反应中更大的试验间变异性(TTV)表明该系统更不稳定.然而,这些发现仅在幅度上而不是在神经反应的时间上被确定，在精神分裂症中还没有得到充分的探索。在自闭症的听觉失配阴性（MMN）中评估了事件相关电位振幅和试验间相干性（ITC）的TTV，精神分裂症,和控制。MMN在自闭症中最大，在精神分裂症中最小，与对照组相比，自闭症和精神分裂症患者的TTV更高。ITC没有差异。更大的TTV似乎是自闭症和精神分裂症的特征，暗示了几种可能导致感觉不稳定的神经机制。
