Abstract：
Anti-D in individuals with a weak D phenotype is an unexpected finding that may require additional investigation to determine whether the anti-D is an autoantibody or alloantibody. Further investigation may also include assessment of the patient\'s RHD genotype and exclusion of anti-G. We present a case of an 84-year-old man with the weak D type 2 genotype who developed an unexpected anti-D along with anti-C. Individuals with the weak D type 2 genotype are thought not to be at risk for developing alloanti-D, although the distinction between alloanti-D and autoanti-D may be difficult to ascertain. Furthermore, investigations may affect transfusion recommendations. This patient was restricted to crossmatch-compatible, D-C- red blood cells even though the clinical significance of the anti-D was uncertain. This report is one of a few reported cases of an individual with the weak D type 2 genotype with demonstrable anti-D but without evidence for alloanti-D.
摘要：
具有弱D表型的个体中的抗D是一个意外的发现,其可能需要额外的研究以确定抗D是自身抗体还是同种抗体。进一步的调查还可能包括评估患者的RHD基因型和排除抗G。我们介绍了一个84岁的男性，患有弱D型2基因型，他产生了意想不到的抗D和抗C。具有弱D型2基因型的个体被认为没有发生同种异体D的风险，尽管alloanti-D和autoanti-D之间的区别可能难以确定。此外，调查可能会影响输血建议。这个病人被限制为交叉配伍，D-C-红细胞，尽管抗D的临床意义不确定。本报告是少数报道的具有弱D型2基因型的个体的病例之一，具有可证明的抗D，但没有同种异体D的证据。
