{Reference Type}: Case Reports
{Title}: Investigating anti-D in an individual with the weak D type 2 genotype.
{Author}: Phou S;Nguyen N;Revilla J;Rodberg K;Gibb DR;Pepkowitz SH;Klapper EB;Phou S;Nguyen N;Revilla J;Rodberg K;Gibb DR;Pepkowitz SH;Klapper EB;Phou S;Nguyen N;Revilla J;Rodberg K;Gibb DR;Pepkowitz SH;Klapper EB;Phou S;Nguyen N;Revilla J;Rodberg K;Gibb DR;Pepkowitz SH;Klapper EB;
{Journal}: Immunohematology
{Volume}: 38
{Issue}: 3
{Year}: Sep 2022 1
暂无{DOI}: 10.21307/immunohematology-2022-046
{Abstract}: Anti-D in individuals with a weak D phenotype is an unexpected finding that may require additional investigation to determine whether the anti-D is an autoantibody or alloantibody. Further investigation may also include assessment of the patient's RHD genotype and exclusion of anti-G. We present a case of an 84-year-old man with the weak D type 2 genotype who developed an unexpected anti-D along with anti-C. Individuals with the weak D type 2 genotype are thought not to be at risk for developing alloanti-D, although the distinction between alloanti-D and autoanti-D may be difficult to ascertain. Furthermore, investigations may affect transfusion recommendations. This patient was restricted to crossmatch-compatible, D-C- red blood cells even though the clinical significance of the anti-D was uncertain. This report is one of a few reported cases of an individual with the weak D type 2 genotype with demonstrable anti-D but without evidence for alloanti-D.