关键词: Antimicrobial peptides Chimaera Harriottin Histone H2A Neoharriotta pinnatta

来  源:   DOI:10.1016/j.dci.2022.104554

Abstract:
Antimicrobial peptides (AMPs) are gene encoded short peptides which play an important role in the innate immunity of almost all living organisms ranging from bacteria to mammals. Histones play a very important role in defense as precursors to bioactive peptides. The present study is an attempt to decipher the antimicrobial activity of a histone H2A derived peptide, Harriottin-1 from sicklefin chimaera, Neoharriotta pinnata. Analysis in silico predicted the molecule with potent antibacterial and anticancer property. The Harriottin-1 was recombinantly produced and the recombinant peptide rHar-1 demonstrated potent antibacterial activity at 25 μM besides anticancer activity. The study strongly suggests the importance of histone H2A derived peptides as a model for the design and synthesis of potent peptide drugs.
摘要:
抗菌肽(AMP)是基因编码的短肽,在从细菌到哺乳动物的几乎所有生物体的先天免疫中起重要作用。组蛋白作为生物活性肽的前体在防御中起着非常重要的作用。本研究试图破译组蛋白H2A衍生肽的抗菌活性,来自镰刀菌嵌合体的Harriottin-1,Neoharriottapinnata.硅分析预测了具有有效抗菌和抗癌性质的分子。Harriottin-1是重组产生的,重组肽rHar-1在25μM时显示出除抗癌活性外的有效抗菌活性。该研究强烈表明组蛋白H2A衍生肽作为设计和合成有效肽药物的模型的重要性。
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