%0 Journal Article
%T Functional characterization of a histone H2A derived antimicrobial peptide HARRIOTTIN-1 from sicklefin chimaera, Neoharriotta pinnata.
%A Sathyan N
%A Muhammed Musthafa S
%A Anju MV
%A Archana K
%A Athira PP
%A Prathap N
%A Chaithanya ER
%A Priyaja P
%A Bright Singh IS
%A Philip R
%J Dev Comp Immunol
%V 138
%N 0
%D Sep 2022 19
%M 36185036
%F 3.605
%R 10.1016/j.dci.2022.104554
%X Antimicrobial peptides (AMPs) are gene encoded short peptides which play an important role in the innate immunity of almost all living organisms ranging from bacteria to mammals. Histones play a very important role in defense as precursors to bioactive peptides. The present study is an attempt to decipher the antimicrobial activity of a histone H2A derived peptide, Harriottin-1 from sicklefin chimaera, Neoharriotta pinnata. Analysis in silico predicted the molecule with potent antibacterial and anticancer property. The Harriottin-1 was recombinantly produced and the recombinant peptide rHar-1 demonstrated potent antibacterial activity at 25 μM besides anticancer activity. The study strongly suggests the importance of histone H2A derived peptides as a model for the design and synthesis of potent peptide drugs.