{Reference Type}: Journal Article
{Title}: Functional characterization of a histone H2A derived antimicrobial peptide HARRIOTTIN-1 from sicklefin chimaera, Neoharriotta pinnata.
{Author}: Sathyan N;Muhammed Musthafa S;Anju MV;Archana K;Athira PP;Prathap N;Chaithanya ER;Priyaja P;Bright Singh IS;Philip R;
{Journal}: Dev Comp Immunol
{Volume}: 138
{Issue}: 0
{Year}: Sep 2022 19
{Factor}: 3.605
{DOI}: 10.1016/j.dci.2022.104554
{Abstract}: Antimicrobial peptides (AMPs) are gene encoded short peptides which play an important role in the innate immunity of almost all living organisms ranging from bacteria to mammals. Histones play a very important role in defense as precursors to bioactive peptides. The present study is an attempt to decipher the antimicrobial activity of a histone H2A derived peptide, Harriottin-1 from sicklefin chimaera, Neoharriotta pinnata. Analysis in silico predicted the molecule with potent antibacterial and anticancer property. The Harriottin-1 was recombinantly produced and the recombinant peptide rHar-1 demonstrated potent antibacterial activity at 25 μM besides anticancer activity. The study strongly suggests the importance of histone H2A derived peptides as a model for the design and synthesis of potent peptide drugs.