Abstract：
Caffeine is one of the most widely used substances as recreational drug for performance-enhancement in sport, underpinned by a strong evidence base. Although the effects of caffeine are widely investigated within the scope of performance physiology, the molecular effects of caffeine within skeletal muscle remain unclear. Evidence from in vitro and in vivo models suggest that caffeine regulates the glucose metabolism in the skeletal muscle. Moreover, caffeine seems to stimulate CaMKII, PPARδ/β, AMPK and PGC1α, classical markers of exercise-adaptations, including mitochondrial biogenesis and mitochondrial content. This review summarizes evidence to suggest caffeine-effects within skeletal muscle fibers, focusing on the putative role of caffeine on mitochondrial biogenesis to explore whether caffeine supplementation might be a strategy to enhance mitochondrial biogenesis.
摘要：
咖啡因是最广泛使用的物质之一，作为娱乐性药物，用于提高运动性能，以强有力的证据为基础。尽管咖啡因的影响在性能生理学的范围内被广泛研究，咖啡因在骨骼肌中的分子效应尚不清楚.来自体外和体内模型的证据表明，咖啡因调节骨骼肌中的葡萄糖代谢。此外，咖啡因似乎能刺激CaMKII,PPARδ/β,AMPK和PGC1α，运动适应的经典标记，包括线粒体生物发生和线粒体含量。这篇综述总结了证据，表明骨骼肌纤维内的咖啡因作用，关注咖啡因对线粒体生物发生的假定作用，以探讨咖啡因补充是否可能是增强线粒体生物发生的策略。
