Abstract：
Lewy body dementia (LBD) refers to both dementia with Lewy bodies (DLB) and Parkinson\'s disease with dementia (PDD). Sleep disturbances are common in LBD, and can include poor sleep quality, excessive daytime sleepiness (EDS), and rapid eye movement behaviour disorder (RBD). Despite the high clinical prevalence of sleep disturbances in LBD, they are under-studied relative to other dementias. The aim of the present systematic review was to examine the nature of sleep disturbances in LBD, summarise the effect of treatment studies upon sleep, and highlight specific and necessary directions for future research.
Published studies in English were located by searching PubMED and PSYCArticles databases (until 10 June 2022). The search protocol was pre-registered in PROSPERO (CRD42021293490) and performed in accordance with PRISMA guidelines.
Following full-text review, a final total of 70 articles were included. These included 20 studies focussing on subjective sleep, 14 on RBD, 8 on EDS, 7 on objective sleep, and 1 on circadian rhythms. The majority of the 18 treatment studies used pharmacological interventions (n = 12), had an open-label design (n = 8), and were of low-to-moderate quality. Most studies (n = 55) included only patients with DLB. Due to the heterogeneity of the studies, we reported a narrative synthesis without meta-analysis.
At least one form of sleep disturbance may be present in as many as 90% of people with LBD. Subjectively poor sleep quality, excessive daytime sleepiness, and RBD are more common and severe in LBD relative to other dementias.
Published studies in English were located by searching PubMED and PSYCArticles databases (until 10 June 2022). The search protocol was pre-registered in PROSPERO (CRD42021293490) and performed in accordance with PRISMA guidelines.
Following full-text review, a final total of 70 articles were included. These included 20 studies focussing on subjective sleep, 14 on RBD, 8 on EDS, 7 on objective sleep, and 1 on circadian rhythms. The majority of the 18 treatment studies used pharmacological interventions (n = 12), had an open-label design (n = 8), and were of low-to-moderate quality. Most studies (n = 55) included only patients with DLB. Due to the heterogeneity of the studies, we reported a narrative synthesis without meta-analysis.
At least one form of sleep disturbance may be present in as many as 90% of people with LBD. Subjectively poor sleep quality, excessive daytime sleepiness, and RBD are more common and severe in LBD relative to other dementias.
摘要：
路易体痴呆(LBD)指路易体痴呆(DLB)和帕金森病痴呆(PDD)。睡眠障碍在LBD中很常见，包括睡眠质量差，白天过度嗜睡（EDS），和快速眼动行为障碍（RBD）。尽管LBD中睡眠障碍的临床患病率很高，相对于其他痴呆症，它们的研究不足。本系统综述的目的是研究LBD中睡眠障碍的性质。总结治疗研究对睡眠的影响，并强调未来研究的具体和必要方向。
通过搜索PubMED和PSYCarticles数据库（直到2022年6月10日）找到了英文发表的研究。搜索方案在PROSPERO(CRD42021293490)中预先注册,并根据PRISMA指南进行。
在全文回顾之后，最终共包括70篇文章。其中包括20项关于主观睡眠的研究，14在RBD上，8在EDS上，7关于客观睡眠，和1昼夜节律。18项治疗研究中的大多数使用了药物干预(n=12)，具有开放标签设计(n=8)，质量低到中等。大多数研究（n=55）仅包括DLB患者。由于研究的异质性，我们报告了没有荟萃分析的叙述性综合。
至少一种形式的睡眠障碍可能存在于多达90%的LBD患者中。主观睡眠质量差，白天过度嗜睡，与其他痴呆相比，RBD在LBD中更为常见和严重。
通过搜索PubMED和PSYCarticles数据库（直到2022年6月10日）找到了英文发表的研究。搜索方案在PROSPERO(CRD42021293490)中预先注册,并根据PRISMA指南进行。
在全文回顾之后，最终共包括70篇文章。其中包括20项关于主观睡眠的研究，14在RBD上，8在EDS上，7关于客观睡眠，和1昼夜节律。18项治疗研究中的大多数使用了药物干预(n=12)，具有开放标签设计(n=8)，质量低到中等。大多数研究（n=55）仅包括DLB患者。由于研究的异质性，我们报告了没有荟萃分析的叙述性综合。
至少一种形式的睡眠障碍可能存在于多达90%的LBD患者中。主观睡眠质量差，白天过度嗜睡，与其他痴呆相比，RBD在LBD中更为常见和严重。
