Published studies in English were located by searching PubMED and PSYCArticles databases (until 10 June 2022). The search protocol was pre-registered in PROSPERO (CRD42021293490) and performed in accordance with PRISMA guidelines.
Following full-text review, a final total of 70 articles were included. These included 20 studies focussing on subjective sleep, 14 on RBD, 8 on EDS, 7 on objective sleep, and 1 on circadian rhythms. The majority of the 18 treatment studies used pharmacological interventions (n = 12), had an open-label design (n = 8), and were of low-to-moderate quality. Most studies (n = 55) included only patients with DLB. Due to the heterogeneity of the studies, we reported a narrative synthesis without meta-analysis.
At least one form of sleep disturbance may be present in as many as 90% of people with LBD. Subjectively poor sleep quality, excessive daytime sleepiness, and RBD are more common and severe in LBD relative to other dementias.
通过搜索PubMED和PSYCarticles数据库(直到2022年6月10日)找到了英文发表的研究。搜索方案在PROSPERO(CRD42021293490)中预先注册,并根据PRISMA指南进行。
在全文回顾之后,最终共包括70篇文章。其中包括20项关于主观睡眠的研究,14在RBD上,8在EDS上,7关于客观睡眠,和1昼夜节律。18项治疗研究中的大多数使用了药物干预(n=12),具有开放标签设计(n=8),质量低到中等。大多数研究(n=55)仅包括DLB患者。由于研究的异质性,我们报告了没有荟萃分析的叙述性综合。
至少一种形式的睡眠障碍可能存在于多达90%的LBD患者中。主观睡眠质量差,白天过度嗜睡,与其他痴呆相比,RBD在LBD中更为常见和严重。