PDF(Pubmed)
Abstract：
UNASSIGNED: precocious puberty is defined as the development of sexual characteristics before 8 years of age in girls and 9 years of age in boys. The purpose of our study was to describe the clinical, paraclinical and etiological profile of precocious puberty.
UNASSIGNED: we conducted a retrospective descriptive study from 1999 to 2017 in the Pediatric Endocrinology Unit at the Rabat Children\'s Hospital.
UNASSIGNED: ninety-nine children were included in the study. The average age of girls was 4.25 ± 2.6 years, while that of boys was 3.6 ± 1.8 years. There was a female predominance (90%; 90 girls). The telltale signs in girls were dominated by breast development (77.77%). In boys, the most common reason for consultation was pubic hair (70%). Biologically, in central precocious puberty, the mean peak LH level after GnRH stimulation was high (17 IU/L) with a mean peak LH to peak FSH ratio of 1.30. The causes included: dissociated early puberty (60.60%), pathological early puberty (39.40%). In the latter, we noted a predominance of precocious pseudopuberty (58.98%). Concerning the central precocious puberty, idiopathic central precocious puberty was the most common etiology in girls (62.5%). In all boys, central nervous system lesion was found.
UNASSIGNED: our study confirms that central pathological precocious puberty is often related to a lesion of the central nervous system in boys, thus justifying systematic brain imaging.
UNASSIGNED: we conducted a retrospective descriptive study from 1999 to 2017 in the Pediatric Endocrinology Unit at the Rabat Children\'s Hospital.
UNASSIGNED: ninety-nine children were included in the study. The average age of girls was 4.25 ± 2.6 years, while that of boys was 3.6 ± 1.8 years. There was a female predominance (90%; 90 girls). The telltale signs in girls were dominated by breast development (77.77%). In boys, the most common reason for consultation was pubic hair (70%). Biologically, in central precocious puberty, the mean peak LH level after GnRH stimulation was high (17 IU/L) with a mean peak LH to peak FSH ratio of 1.30. The causes included: dissociated early puberty (60.60%), pathological early puberty (39.40%). In the latter, we noted a predominance of precocious pseudopuberty (58.98%). Concerning the central precocious puberty, idiopathic central precocious puberty was the most common etiology in girls (62.5%). In all boys, central nervous system lesion was found.
UNASSIGNED: our study confirms that central pathological precocious puberty is often related to a lesion of the central nervous system in boys, thus justifying systematic brain imaging.
摘要：
未经评估：性早熟被定义为女孩在8岁之前和男孩在9岁之前的性特征发育。我们研究的目的是描述临床，性早熟的临床和病因学特征。
UNASSIGNED：我们于1999年至2017年在拉巴特儿童医院儿科内分泌科进行了一项回顾性描述性研究。
未经评估：99名儿童被纳入研究。女童平均年龄4.25±2.6岁,而男孩的年龄为3.6±1.8岁。女性占主导地位（90％；90名女孩）。女孩的明显迹象主要是乳房发育（77.77％）。在男孩中，咨询的最常见原因是阴毛(70%)。生物学,在中部性早熟，GnRH刺激后的平均LH峰值水平较高(17IU/L),平均LH峰值与FSH峰值比值为1.30.原因包括：分离的青春期早期（60.60％），病理性青春期早期(39.40%)。在后者中,我们注意到假性早熟占主导地位(58.98%)。关于中央性早熟，特发性中枢性性早熟是女孩最常见的病因(62.5%)。在所有男孩中，发现中枢神经系统病变。
UNASSIGNED：我们的研究证实，中枢神经病理性性早熟通常与男孩的中枢神经系统病变有关，从而证明系统的大脑成像是合理的。
UNASSIGNED：我们于1999年至2017年在拉巴特儿童医院儿科内分泌科进行了一项回顾性描述性研究。
未经评估：99名儿童被纳入研究。女童平均年龄4.25±2.6岁,而男孩的年龄为3.6±1.8岁。女性占主导地位（90％；90名女孩）。女孩的明显迹象主要是乳房发育（77.77％）。在男孩中，咨询的最常见原因是阴毛(70%)。生物学,在中部性早熟，GnRH刺激后的平均LH峰值水平较高(17IU/L),平均LH峰值与FSH峰值比值为1.30.原因包括：分离的青春期早期（60.60％），病理性青春期早期(39.40%)。在后者中,我们注意到假性早熟占主导地位(58.98%)。关于中央性早熟，特发性中枢性性早熟是女孩最常见的病因(62.5%)。在所有男孩中，发现中枢神经系统病变。
UNASSIGNED：我们的研究证实，中枢神经病理性性早熟通常与男孩的中枢神经系统病变有关，从而证明系统的大脑成像是合理的。
