Abstract：
Functional dyspepsia is the actual problem of modern gastroenterology, its manifestations contribute to the lifting of lifestyle and nutrition. However, a comprehensive assessment of the effect of violations of food behavior, the distribution of adipose tissue and the level of gosters regulating appetite on the severity of gastroenterological symptoms in individuals with various types of functional dyspepsia hasn\'t been carried out yet. Aim - to clarify the effect of food behavior, ghrelin and leptin blood concentrations on clinical symptoms in patients with different types of functional dyspepsia. Material and methods. A prospective study with the participation of 90 people aged 22.3±0.2, divided into 3 groups was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), and practically healthy. All respondents were interviewed using the GSRS, DEBQ questionnaires, their anthropometric data have been defined, body composition indicators were calculated based on the measurement of body circumference measurements, leptin and ghrelin concentration in blood serum was measured by the enzyme immunoassay method. Results and discussion. EPS was characterized by more pronounced symptoms (10.10±0.32 points on the GSRS questionnaire) due to abdominal pain syndrome (4.33±0.51 points) compared with patients with PDS and healthy individuals. In both variants of the functional dyspepsia, all three types of food behavior disorders were revealed, however, the external type was more characteristic for PDS. Patients with PDS had a larger volume of visceral adipose tissue (42.84% of the total fat tissue in the body) than those with EPS (34.02%) and healthy ones (35.55%). Blood leptin concentration in patients with both variants of the functional dyspepsia was lower (especially in patients with EPS - 0.17±0.03 ng/ml, p=0.039) than in healthy (0.32±0.08 ng/ml). Ghrelin level in patients with EPS (14.91±0.17 ng/ml) was significantly higher than in healthy (11.55±0.44 ng/ml, p=0.022). Factor analysis made it possible to identify the stress factor showing the connection of emotional disorders of food behavior with increasing gastrointestinal symptoms and blood leptin concentration and decreasing blood ghrelin level. Conclusion. Different variants of functional dyspepsia are characterized by their own peculiarities of eating behavior, the distribution of fat in the body, the degree of changes in leptin and ghrelin levels, which determine their clinical symptoms. The identification and accounting of these factors will make it possible to individualize the approach to the curation of patients with functional dyspepsia.
摘要：
功能性消化不良是现代胃肠病学的实际问题，它的表现有助于提升生活方式和营养。然而,全面评估违反食品行为的影响，在各种功能性消化不良患者中，脂肪组织的分布和调节食欲的水平对胃肠病症状的严重程度的影响尚未进行。目的-阐明食物行为的影响，ghrelin和瘦素血药浓度对不同类型功能性消化不良患者临床症状的影响。材料和方法。对90名年龄在22.3±0.2岁的人进行了一项前瞻性研究，分为3组：餐后窘迫综合征（PDS）患者，上腹痛综合征（EPS）患者，实际上是健康的。所有受访者都使用GSRS进行了采访，DEBQ问卷，他们的人体测量数据已经确定，身体成分指标是根据身体周长测量值计算的，用酶免疫分析法测定血清中瘦素和生长素释放肽的浓度。结果和讨论。与PDS患者和健康个体相比，EPS的特征是由于腹痛综合征（4.33±0.51分）引起的症状更明显（GSRS问卷上的10.10±0.32分）。在功能性消化不良的两种变体中，所有三种类型的食物行为障碍都被揭示，然而,外部类型对PDS更具特征性。与EPS患者（34.02％）和健康患者（35.55％）相比，PDS患者的内脏脂肪组织体积更大（占体内总脂肪组织的42.84％）。两种功能性消化不良患者的血瘦素浓度较低（尤其是EPS患者-0.17±0.03ng/ml，p=0.039）比健康（0.32±0.08ng/ml）。EPS患者Ghrelin水平(14.91±0.17ng/ml)明显高于健康者(11.55±0.44ng/ml,p=0.022)。因素分析使确定压力因素成为可能，该压力因素表明食物行为的情绪障碍与胃肠道症状和血液瘦素浓度增加以及血液ghrelin水平降低有关。结论。功能性消化不良的不同变体的特点是它们自己的饮食行为的特殊性，脂肪在体内的分布,瘦素和生长素水平的变化程度，这决定了他们的临床症状。这些因素的识别和核算将有可能个性化治疗功能性消化不良患者的方法。
