METHODS: Patients who received radiotherapy for locally advanced (T3-T4) and pathologic node-negative (N0) squamous cell laryngeal cancer were retrospectively evaluated. Radiotherapy was applied to median 60 Gy (range 54-60 Gy) as selective local radiotherapy (±stoma). The local treatment areas included postoperative bed + laryngeal area for patients with a partial laryngectomy, and the postoperative bed only for patients with total laryngectomy.
RESULTS: The median follow-up time was 59 months and 52 patients were included. The 2‑year, 5‑year, and 8‑year locoregional recurrence controls (LRC) were 95.6%. The 2‑year and 5‑year OS rates were 93.8% and 78.9%, respectively. The 5‑year OS for age < 60 years was 95.8%, for above 60 years 56.5%.
CONCLUSIONS: Our data suggest that local selective irradiation to the postoperative bed + stoma is enough in patients with T3-4 N0 laryngeal cancer without applying elective nodal irradiation.
方法:对接受局部晚期(T3-T4)和病理淋巴结阴性(N0)的鳞状细胞喉癌放疗的患者进行回顾性评估。将放射疗法应用于中位60Gy(范围54-60Gy)作为选择性局部放射疗法(±气孔)。局部治疗区域包括喉部分切除术患者的术后床+喉区,术后床只适用于全喉切除术的患者。
结果:中位随访时间为59个月,共纳入52例患者。2年,5年,8年局部区域复发控制(LRC)为95.6%。2年和5年OS率分别为93.8%和78.9%,分别。年龄<60岁的5年OS为95.8%,60年以上56.5%。
结论:我们的数据表明,对于T3-4N0喉癌患者,不应用选择性淋巴结照射,对术后床+造口进行局部选择性照射就足够了。