{Reference Type}: Journal Article
{Title}: Selective local postoperative radiotherapy for T3-T4 N0 laryngeal cancer.
{Author}: Dağdelen M;Şahin M;Çatal TK;Yıldırım HC;Karaçam SÇ;Çepni K;Uzel ÖE;
{Journal}: Strahlenther Onkol
{Volume}: 0
{Issue}: 0
{Year}: Sep 2022 8
{Factor}: 4.033
{DOI}: 10.1007/s00066-022-01999-y
{Abstract}: <B>OBJECTIVE: </B>We aimed to investigate the appropriate postoperative radiotherapy dose and selective volume in T3-4 N0 laryngeal cancer patients treated with either total or partial laryngectomy.<BR><B>METHODS: </B>Patients who received radiotherapy for locally advanced (T3-T4) and pathologic node-negative (N0) squamous cell laryngeal cancer were retrospectively evaluated. Radiotherapy was applied to median 60 Gy (range 54-60 Gy) as selective local radiotherapy (±stoma). The local treatment areas included postoperative bed + laryngeal area for patients with a partial laryngectomy, and the postoperative bed only for patients with total laryngectomy.<BR><B>RESULTS: </B>The median follow-up time was 59 months and 52 patients were included. The 2‑year, 5‑year, and 8‑year locoregional recurrence controls (LRC) were 95.6%. The 2‑year and 5‑year OS rates were 93.8% and 78.9%, respectively. The 5‑year OS for age < 60 years was 95.8%, for above 60 years 56.5%.<BR><B>CONCLUSIONS: </B>Our data suggest that local selective irradiation to the postoperative bed + stoma is enough in patients with T3-4 N0 laryngeal cancer without applying elective nodal irradiation.