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Abstract：
UNASSIGNED: Quantitative electroencephalography (QEEG) is a reliable and non-invasive diagnostic tool to quantify cortical synaptic injury or loss in the clinical assessment of neurodegenerative diseases, and may be able to differentiate various types of dementia. We investigated if QEEG indices can differentiate Parkinson\'s Disease (PD) with nondementia (PD-ND) from PD with dementia (PDD), and to determine if QEEG indices correlate with inflammation and lipid metabolism markers in PD.
UNASSIGNED: This clinical study collected data between July 1, 2018 and July 1, 2021 in Zhujiang Hospital of Southern Medical University in China and data was analysed. A total of 125 individuals comprising of 31 PDD, 47 patients with PD-ND and 47 healthy controls were included. We calculated the absolute spectral power (ASP) of frequency bands and the slow-to-fast frequency ratios of specific brain regions. Plasma levels of hypersensitive C-reactive protein (Hs-CRP), superoxide dismutase (SOD), and high-density lipoprotein cholesterol (HDL-C) were measured and correlations with QEEG indices were examined.
UNASSIGNED: A significantly higher ASP of delta frequency especially in the frontal region was observed in patients with PDD compared to PD-ND (P=0.004) and controls (P=0.000). Decreased HDL-C (OR=0.186, P=0.030), and increased Hs-CRP (OR =2.856, P=0.015) were associated with PDD. Frontal-delta ASP was negatively correlated with plasma HDL-C (r=-0.353, P=0.000) and SOD (r=-0.322, P=0.001), and positively correlated with Hs-CRP (r=0.342, P=0.000).
UNASSIGNED: We highlight novel correlations between QEEG indices and inflammation and lipid metabolism markers in PD-ND and PDD. QEEG indices, HDL-C and Hs-CRP are potentially useful for the evaluation of PDD. Our current findings suggest that peripheral inflammation might contribute to the pathogenesis of cognitive impairment and EEG slowing in PDD. The mechanism underlying frontal-delta ASP and its correlation with neuro-inflammatory and metabolic markers in PDD should be further investigated.
UNASSIGNED: The National Natural Science Foundation of China (NO: 81873777, 82071414); the Scientific Research Foundation of Guangzhou (NO: 202206010005); the Science and Technology Program of Guangdong of China (NO: 2020A0505100037); the High-level Hospital Construction Research Project of Maoming People\'s Hospital (NO: xz2020009); the Science and Technology Program of Maoming City (NO: 2021S0026). Dr EK Tan is supported by the National Medical Research Council, Singapore.
UNASSIGNED: This clinical study collected data between July 1, 2018 and July 1, 2021 in Zhujiang Hospital of Southern Medical University in China and data was analysed. A total of 125 individuals comprising of 31 PDD, 47 patients with PD-ND and 47 healthy controls were included. We calculated the absolute spectral power (ASP) of frequency bands and the slow-to-fast frequency ratios of specific brain regions. Plasma levels of hypersensitive C-reactive protein (Hs-CRP), superoxide dismutase (SOD), and high-density lipoprotein cholesterol (HDL-C) were measured and correlations with QEEG indices were examined.
UNASSIGNED: A significantly higher ASP of delta frequency especially in the frontal region was observed in patients with PDD compared to PD-ND (P=0.004) and controls (P=0.000). Decreased HDL-C (OR=0.186, P=0.030), and increased Hs-CRP (OR =2.856, P=0.015) were associated with PDD. Frontal-delta ASP was negatively correlated with plasma HDL-C (r=-0.353, P=0.000) and SOD (r=-0.322, P=0.001), and positively correlated with Hs-CRP (r=0.342, P=0.000).
UNASSIGNED: We highlight novel correlations between QEEG indices and inflammation and lipid metabolism markers in PD-ND and PDD. QEEG indices, HDL-C and Hs-CRP are potentially useful for the evaluation of PDD. Our current findings suggest that peripheral inflammation might contribute to the pathogenesis of cognitive impairment and EEG slowing in PDD. The mechanism underlying frontal-delta ASP and its correlation with neuro-inflammatory and metabolic markers in PDD should be further investigated.
UNASSIGNED: The National Natural Science Foundation of China (NO: 81873777, 82071414); the Scientific Research Foundation of Guangzhou (NO: 202206010005); the Science and Technology Program of Guangdong of China (NO: 2020A0505100037); the High-level Hospital Construction Research Project of Maoming People\'s Hospital (NO: xz2020009); the Science and Technology Program of Maoming City (NO: 2021S0026). Dr EK Tan is supported by the National Medical Research Council, Singapore.
摘要：
UASSIGNED：定量脑电图（QEEG）是一种可靠且无创的诊断工具，可在神经退行性疾病的临床评估中量化皮质突触损伤或损失，并且可能能够区分各种类型的痴呆症。我们调查了QEEG指标是否可以区分帕金森病（PD）非痴呆（PD-ND）和PD痴呆（PDD），并确定QEEG指标是否与PD中的炎症和脂质代谢标志物相关。
UNASSIGNED：本临床研究收集了中国南方医科大学珠江医院2018年7月1日至2021年7月1日的数据，并对数据进行了分析。总共125个人，包括31个PDD，纳入47例PD-ND患者和47例健康对照。我们计算了频带的绝对频谱功率（ASP）和特定大脑区域的慢速与快速频率比。超敏C反应蛋白（Hs-CRP）的血浆水平，超氧化物歧化酶（SOD），测量高密度脂蛋白胆固醇（HDL-C），并检查与QEEG指标的相关性。
UNASSIGNED：与PD-ND（P=0.004）和对照组（P=0.000）相比，PDD患者的delta频率的ASP明显更高，尤其是在额叶区域。HDL-C降低(OR=0.186,P=0.030),Hs-CRP升高(OR=2.856,P=0.015)与PDD相关。额-δASP与血浆HDL-C(r=-0.353,P=0.000)、SOD(r=-0.322,P=0.001)呈负相关,与Hs-CRP呈正相关(r=0.342,P=0.000)。
未经证实：我们强调了PD-ND和PDD中QEEG指标与炎症和脂质代谢标志物之间的新相关性。QEEG指数，HDL-C和Hs-CRP可能用于PDD的评估。我们目前的发现表明，外周炎症可能有助于PDD中认知障碍和EEG减慢的发病机理。额叶-δASP的潜在机制及其与PDD中神经炎症和代谢标志物的相关性有待进一步研究。
UNASSIGNED:国家自然科学基金项目(编号:81873777,82071414);广州市科研基金项目(编号:202206010005);广东省科技项目(编号:202020A0505100037);茂名市人民医院高级医院建设研究项目(编号:2021茂名科技项目);EKTan博士得到了国家医学研究委员会的支持，新加坡。
UNASSIGNED：本临床研究收集了中国南方医科大学珠江医院2018年7月1日至2021年7月1日的数据，并对数据进行了分析。总共125个人，包括31个PDD，纳入47例PD-ND患者和47例健康对照。我们计算了频带的绝对频谱功率（ASP）和特定大脑区域的慢速与快速频率比。超敏C反应蛋白（Hs-CRP）的血浆水平，超氧化物歧化酶（SOD），测量高密度脂蛋白胆固醇（HDL-C），并检查与QEEG指标的相关性。
UNASSIGNED：与PD-ND（P=0.004）和对照组（P=0.000）相比，PDD患者的delta频率的ASP明显更高，尤其是在额叶区域。HDL-C降低(OR=0.186,P=0.030),Hs-CRP升高(OR=2.856,P=0.015)与PDD相关。额-δASP与血浆HDL-C(r=-0.353,P=0.000)、SOD(r=-0.322,P=0.001)呈负相关,与Hs-CRP呈正相关(r=0.342,P=0.000)。
未经证实：我们强调了PD-ND和PDD中QEEG指标与炎症和脂质代谢标志物之间的新相关性。QEEG指数，HDL-C和Hs-CRP可能用于PDD的评估。我们目前的发现表明，外周炎症可能有助于PDD中认知障碍和EEG减慢的发病机理。额叶-δASP的潜在机制及其与PDD中神经炎症和代谢标志物的相关性有待进一步研究。
UNASSIGNED:国家自然科学基金项目(编号:81873777,82071414);广州市科研基金项目(编号:202206010005);广东省科技项目(编号:202020A0505100037);茂名市人民医院高级医院建设研究项目(编号:2021茂名科技项目);EKTan博士得到了国家医学研究委员会的支持，新加坡。
