Kr ü ppel 样因子 5 重新连接 NANOG 调节网络以激活人类幼稚多能性特异性 LTR7Y 并促进幼稚多能性。
关键词: CP: stem cell research ERVs KLFs cell potency naive and primed pluripotency transcription control trophectoderm CP: stem cell research ERVs KLFs cell potency naive and primed pluripotency transcription control trophectoderm CP: stem cell research ERVs KLFs cell potency naive and primed pluripotency transcription control trophectoderm
Mesh : Blastocyst / metabolism Cell Differentiation Embryonic Stem Cells / metabolism Gene Expression Regulation, Developmental Humans Kruppel-Like Transcription Factors / genetics metabolism Nanog Homeobox Protein / genetics metabolism Pluripotent Stem Cells / metabolism Transcription Factors / metabolism Animals Blastocyst / metabolism Cell Differentiation Embryonic Stem Cells / metabolism Gene Expression Regulation, Developmental Humans Kruppel-Like Transcription Factors / genetics metabolism Mammals / metabolism Nanog Homeobox Protein / genetics metabolism Pluripotent Stem Cells / metabolism Transcription Factors / metabolism
来 源: DOI:10.1016/j.celrep.2022.111240