繁殖对动物至关重要。为了成功,社会行为的协调,生理学,配子的生产是必要的。社会线索是如何感知的,它们是如何影响生理和配子生成的?而女性,从昆虫到哺乳动物,提供了关于这种协调的多种见解,它的存在在男性中仍然未知。这里,通过使用果蝇雄性作为模型,我们描述了一种现象,通过这种现象,潜在的交配伙伴的可用性触发了睾丸干细胞群的激活状态,促进精子发生.我们揭示了它对信息素通信的依赖,即使在没有交配或与雌性的其他互动的情况下。最后,我们确定了器官间通讯信号网络负责肌肉分泌的肿瘤坏死因子α(TNF-α)/Eiger和神经分泌的章鱼胺触发剂,分别,Jun氨基末端激酶(JNK)途径和囊肿干细胞中钙动力学的变化。因此,生殖系干细胞增加其增殖。
Reproduction is paramount to animals. For it to be successful, a coordination of social behavior, physiology, and gamete production is necessary. How are social cues perceived and how do they affect physiology and gametogenesis? While females, ranging from insects to mammals, have provided multiple insights about this coordination, its existence remains largely unknown in males. Here, by using the Drosophila male as a model, we describe a phenomenon by which the availability of potential mating partners triggers an activation state on the stem cell populations of the testis, boosting spermatogenesis. We reveal its reliance on pheromonal communication, even in the absence of mating or other interactions with females. Finally, we identify the interorgan communication signaling network responsible-muscle-secreted tumor necrosis factor alpha (TNF-α)/Eiger and neuronally secreted octopamine trigger, respectively, the Jun N-terminal kinase (JNK) pathway and a change in calcium dynamics in the cyst stem cells. As a consequence, germ line stem cells increase their proliferation.