Abstract：
Curcumin is the most important active component in turmeric extracts. Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancements made in recent years with respect to curcumin as a biologically active agent in malignant tumors, Alzheimer\'s disease (AD), hematological diseases and viral infectious diseases. We also focus on problems associated with curcumin from basic research to clinical translation, such as its low solubility, leading to poor bioavailability, as well as the controversy surrounding the association between curcumin purity and effect. Through a review and summary of the clinical research on curcumin and case reports of adverse effects, we found that the clinical transformation of curcumin is not successful, and excessive intake of curcumin may have adverse effects on the kidneys, heart, liver, blood and immune system, which leads us to warn that curcumin has a long way to go from basic research to application transformation.
摘要：
姜黄素是姜黄提取物中最重要的活性成分。姜黄素,一种来自植物的天然单体作为膳食补充剂受到了相当大的关注，在广泛的人类病理条件下表现出明显的活性。总的来说,姜黄素有益于人体健康,表现出抗炎和抗氧化的药理活性，以及抗肿瘤和免疫调节活性。姜黄素还具有治疗神经退行性疾病的潜力，心脑血管疾病。在这篇评论文章中，我们总结了近年来姜黄素作为恶性肿瘤生物活性剂的研究进展，阿尔茨海默病（AD），血液病和病毒性传染病。我们还关注与姜黄素相关的问题，从基础研究到临床翻译，例如它的低溶解度，导致生物利用度差，以及围绕姜黄素纯度和效果之间关联的争议。通过回顾和总结姜黄素的临床研究和不良反应的病例报告,我们发现姜黄素的临床转化并不成功，过量摄入姜黄素可能会对肾脏产生不良影响，心,肝脏,血液和免疫系统，这导致我们警告说，姜黄素从基础研究到应用转化还有很长的路要走。
