TRP 家族通道在恶性肿瘤中的调控作用及相关治疗策略.
关键词: 4α-PDD, 4α-phorbol-12,13-didecanoate ABCB, ATP-binding cassette B1 AKT, protein kinase B ALA, alpha lipoic acid AMPK, AMP-activated protein kinase APB, aminoethoxydiphenyl borate ATP, adenosine triphosphate CBD, cannabidiol CRAC, Ca2+ release-activated Ca2+ channel CaR, calcium-sensing receptor CaSR, calcium sensing receptor Cancer progression DAG, diacylglycerol DBTRG, Denver Brain Tumor Research Group ECFC, endothelial colony-forming cells ECM, enhanced extracellular matrix EGF, epidermal growth factor EMT, epithelial–mesenchymal transition ER, endoplasmic reticulum ERK, extracellular signal-regulated kinase ETS, erythroblastosis virus E26 oncogene homolog FAK, focal adhesion kinase GADD, growth arrest and DNA damage-inducible gene GC, gastric cancer GPCR, G-protein coupled receptor GSC, glioma stem-like cells GSK, glycogen synthase kinase HCC, hepatocellular carcinoma HIF, hypoxia-induced factor HSC, hematopoietic stem cells IP3R, inositol triphosphate receptor Intracellular mechanism KO, knockout LOX, lipoxygenase LPS, lipopolysaccharide LRP, lipoprotein receptor-related protein MAPK, mitogen-activated protein kinase MLKL, mixed lineage kinase domain-like protein MMP, matrix metalloproteinases NEDD4, neural precursor cell expressed, developmentally down-regulated 4 NFAT, nuclear factor of activated T-cells NLRP3, NLR family pyrin domain containing 3 NO, nitro oxide NSCLC, non-small cell lung cancer Nrf2, nuclear factor erythroid 2-related factor 2 P-gp, P-glycoprotein PCa, prostate cancer PDAC, pancreatic ductal adenocarcinoma PHD, prolyl hydroxylases PI3K, phosphoinositide 3-kinase PKC, protein kinase C PKD, polycystic kidney disease PLC, phospholipase C Programmed cancer cell death RNS/ROS, reactive nitrogen species/reactive oxygen species RTX, resiniferatoxin SMAD, Caenorhabditis elegans protein (Sma) and mothers against decapentaplegic (Mad) SOCE, store operated calcium entry SOR, soricimed STIM1, stromal interaction molecules 1 TEC, tumor endothelial cells TGF, transforming growth factor-β TNF-α, tumor necrosis factor-α TRP channels TRPA/C/M/ML/N/P/V, transient receptor potential ankyrin/canonical/melastatin/mucolipon/NOMPC/polycystin/vanilloid Targeted tumor therapy Tumor microenvironment Tumor-associated immunocytes UPR, unfolded protein response VEGF, vascular endothelial growth factor VIP, vasoactive intestinal peptide VPAC, vasoactive intestinal peptide receptor subtype mTOR, mammalian target of rapamycin pFRG/RTN, parafacial respiratory group/retrotrapezoid nucleus 4α-PDD, 4α-phorbol-12,13-didecanoate ABCB, ATP-binding cassette B1 AKT, protein kinase B ALA, alpha lipoic acid AMPK, AMP-activated protein kinase APB, aminoethoxydiphenyl borate ATP, adenosine triphosphate CBD, cannabidiol CRAC, Ca2+ release-activated Ca2+ channel CaR, calcium-sensing receptor CaSR, calcium sensing receptor Cancer progression DAG, diacylglycerol DBTRG, Denver Brain Tumor Research Group ECFC, endothelial colony-forming cells ECM, enhanced extracellular matrix EGF, epidermal growth factor EMT, epithelial–mesenchymal transition ER, endoplasmic reticulum ERK, extracellular signal-regulated kinase ETS, erythroblastosis virus E26 oncogene homolog FAK, focal adhesion kinase GADD, growth arrest and DNA damage-inducible gene GC, gastric cancer GPCR, G-protein coupled receptor GSC, glioma stem-like cells GSK, glycogen synthase kinase HCC, hepatocellular carcinoma HIF, hypoxia-induced factor HSC, hematopoietic stem cells IP3R, inositol triphosphate receptor Intracellular mechanism KO, knockout LOX, lipoxygenase LPS, lipopolysaccharide LRP, lipoprotein receptor-related protein MAPK, mitogen-activated protein kinase MLKL, mixed lineage kinase domain-like protein MMP, matrix metalloproteinases NEDD4, neural precursor cell expressed, developmentally down-regulated 4 NFAT, nuclear factor of activated T-cells NLRP3, NLR family pyrin domain containing 3 NO, nitro oxide NSCLC, non-small cell lung cancer Nrf2, nuclear factor erythroid 2-related factor 2 P-gp, P-glycoprotein PCa, prostate cancer PDAC, pancreatic ductal adenocarcinoma PHD, prolyl hydroxylases PI3K, phosphoinositide 3-kinase PKC, protein kinase C PKD, polycystic kidney disease PLC, phospholipase C Programmed cancer cell death RNS/ROS, reactive nitrogen species/reactive oxygen species RTX, resiniferatoxin SMAD, Caenorhabditis elegans protein (Sma) and mothers against decapentaplegic (Mad) SOCE, store operated calcium entry SOR, soricimed STIM1, stromal interaction molecules 1 TEC, tumor endothelial cells TGF, transforming growth factor-β TNF-α, tumor necrosis factor-α TRP channels TRPA/C/M/ML/N/P/V, transient receptor potential ankyrin/canonical/melastatin/mucolipon/NOMPC/polycystin/vanilloid Targeted tumor therapy Tumor microenvironment Tumor-associated immunocytes UPR, unfolded protein response VEGF, vascular endothelial growth factor VIP, vasoactive intestinal peptide VPAC, vasoactive intestinal peptide receptor subtype mTOR, mammalian target of rapamycin pFRG/RTN, parafacial respiratory group/retrotrapezoid nucleus
来 源:
DOI:10.1016/j.apsb.2021.11.001
PDF(Pubmed)