Abstract：
OBJECTIVE: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population.
METHODS: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia.
RESULTS: Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001).
CONCLUSIONS: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
METHODS: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia.
RESULTS: Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001).
CONCLUSIONS: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
摘要：
目的：本研究旨在确定日本人群中血清尿酸水平异常或高尿酸血症史与COVID-19严重程度之间的关系。
方法：我们纳入了2020年2月至2021年5月日本COVID-19工作组队列中的1523名患者。我们比较了临床特征，包括合并症，实验室发现,和结果，特别是有创机械通气（IMV），在有和没有异常尿酸水平或高尿酸血症史的患者中。
结果：血清尿酸水平较高的患者年龄较大，体重和体重指数较高。此外,多元logistic回归分析显示,高血尿酸水平或高尿酸血症病史与IMV风险增加之间存在显著关联(比值比[OR]=1.77;P=0.03/OR=1.56;P=0.04).此外，入院时尿酸水平低的患者也与IMV需求显著相关(OR=5.09;P<0.0001).
结论：在日本队列中，血清尿酸水平异常或高尿酸血症史与COVID-19严重程度显著相关。
方法：我们纳入了2020年2月至2021年5月日本COVID-19工作组队列中的1523名患者。我们比较了临床特征，包括合并症，实验室发现,和结果，特别是有创机械通气（IMV），在有和没有异常尿酸水平或高尿酸血症史的患者中。
结果：血清尿酸水平较高的患者年龄较大，体重和体重指数较高。此外,多元logistic回归分析显示,高血尿酸水平或高尿酸血症病史与IMV风险增加之间存在显著关联(比值比[OR]=1.77;P=0.03/OR=1.56;P=0.04).此外，入院时尿酸水平低的患者也与IMV需求显著相关(OR=5.09;P<0.0001).
结论：在日本队列中，血清尿酸水平异常或高尿酸血症史与COVID-19严重程度显著相关。
