{Reference Type}: Journal Article
{Title}: U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task Force.
{Author}: Fukushima T;Chubachi S;Namkoong H;Otake S;Nakagawara K;Tanaka H;Lee H;Morita A;Watase M;Kusumoto T;Masaki K;Kamata H;Ishii M;Hasegawa N;Harada N;Ueda T;Ueda S;Ishiguro T;Arimura K;Saito F;Yoshiyama T;Nakano Y;Mutoh Y;Suzuki Y;Murakami K;Okada Y;Koike R;Kitagawa Y;Kimura A;Imoto S;Miyano S;Ogawa S;Kanai T;Fukunaga K; ;
{Journal}: Int J Infect Dis
{Volume}: 122
{Issue}: 0
{Year}: Sep 2022
{Factor}: 12.074
{DOI}: 10.1016/j.ijid.2022.07.014
{Abstract}: <B>OBJECTIVE: </B>This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population.<BR><B>METHODS: </B>We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia.<BR><B>RESULTS: </B>Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001).<BR><B>CONCLUSIONS: </B>Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.