%0 Journal Article
%T U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task Force.
%A Fukushima T
%A Chubachi S
%A Namkoong H
%A Otake S
%A Nakagawara K
%A Tanaka H
%A Lee H
%A Morita A
%A Watase M
%A Kusumoto T
%A Masaki K
%A Kamata H
%A Ishii M
%A Hasegawa N
%A Harada N
%A Ueda T
%A Ueda S
%A Ishiguro T
%A Arimura K
%A Saito F
%A Yoshiyama T
%A Nakano Y
%A Mutoh Y
%A Suzuki Y
%A Murakami K
%A Okada Y
%A Koike R
%A Kitagawa Y
%A Kimura A
%A Imoto S
%A Miyano S
%A Ogawa S
%A Kanai T
%A Fukunaga K
%A  
%J Int J Infect Dis
%V 122
%N 0
%D Sep 2022
%M 35811077
%F 12.074
%R 10.1016/j.ijid.2022.07.014
%X <B>OBJECTIVE: </B>This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population.<BR><B>METHODS: </B>We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia.<BR><B>RESULTS: </B>Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001).<BR><B>CONCLUSIONS: </B>Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.