Abstract：
Food bioactive components, particularly phytochemicals with antioxidant capacity, have been extensively studied over the past two decades. However, as new analytical and molecular biological tools advance, antioxidants related research has undergone significant paradigm shifts. This review is a high-level overview of the evolution of phytochemical antioxidants research. Early research used chemical models to assess the antioxidant capacity of different phytochemicals, which provided important information about the health potential, but the results were overused and misinterpreted despite the lack of biological relevance (Antioxidants v1.0). This led to findings in the anti-inflammatory properties and modulatory effects of cell signaling of phytochemicals (Antioxidants v2.0). Recent advances in the role of diet in modulating gut microbiota have suggested a new phase of food bioactives research along the phytochemicals-gut microbiota-intestinal metabolites-low-grade inflammation-metabolic syndrome axis (Antioxidants v3.0). Polyphenols and carotenoids were discussed in-depth, and future research directions were also provided.
摘要：
食品生物活性成分,特别是具有抗氧化能力的植物化学物质，在过去的二十年里得到了广泛的研究。然而,随着新的分析和分子生物学工具的发展，抗氧化剂相关研究经历了重大的范式转变。这篇综述是对植物化学抗氧化剂研究进展的高度概述。早期的研究使用化学模型来评估不同植物化学物质的抗氧化能力，提供了关于健康潜力的重要信息，但结果被过度使用和误解，尽管缺乏生物学相关性（抗氧化剂v1.0）。这导致了植物化学物质(抗氧化剂v2.0)的抗炎特性和细胞信号传导的调节作用的发现。饮食在调节肠道微生物群中的作用的最新进展表明，沿着植物化学物质-肠道微生物群-肠道代谢产物-低度炎症-代谢综合征轴（抗氧化剂v3.0）的食品生物活性研究进入了新阶段。对多酚和类胡萝卜素进行了深入的讨论,并提出了今后的研究方向。
