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Abstract：
To study the retinal and choroidal thickness variations on enhanced depth imaging optical coherence tomography scans in ocular albinism (OA) and compare with age-matched healthy subjects.
This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA and age, sex, and axial length-matched control healthy subjects. All patients underwent detailed ophthalmic examination and a single-line horizontal-raster enhanced depth imaging - optical coherence tomography scan (Spectralis, Heidelberg Engineering). Retinal and choroidal thickness was measured, compared, and analyzed between the two groups. Mann-Whitney U test was used for analysis between the two groups. P < 0.05 was considered significant.
The mean age was 28.3 ± 11.6 and 29.9 ± 10.6 years in the OA group and control group, respectively. Spherical equivalents ranged from -8.5D to +10.5D in the OA group and from -8.0D to +10.0D in the control group. The mean axial length between the two groups (P = 0.652) were comparable. The average retinal thickness (272 ± 34.3 vs. 213 ± 13.8 μm; P < 0.001) was greater in the OA group as compared to controls. The mean choroidal thickness (184 ± 78.4 vs. 287 ± 46.4 μm; P < 0.001) was significantly thinner in the OA group.
Acquisition of OCT scans in OA can be challenging. This study showed that the subfoveal retinal thickness and choroidal thickness measured across the scans were significantly different in the OA group compared to controls. In the future, more studies are required to evaluate the role of the choroid and its relationship to emmetropization in albinism.
This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA and age, sex, and axial length-matched control healthy subjects. All patients underwent detailed ophthalmic examination and a single-line horizontal-raster enhanced depth imaging - optical coherence tomography scan (Spectralis, Heidelberg Engineering). Retinal and choroidal thickness was measured, compared, and analyzed between the two groups. Mann-Whitney U test was used for analysis between the two groups. P < 0.05 was considered significant.
The mean age was 28.3 ± 11.6 and 29.9 ± 10.6 years in the OA group and control group, respectively. Spherical equivalents ranged from -8.5D to +10.5D in the OA group and from -8.0D to +10.0D in the control group. The mean axial length between the two groups (P = 0.652) were comparable. The average retinal thickness (272 ± 34.3 vs. 213 ± 13.8 μm; P < 0.001) was greater in the OA group as compared to controls. The mean choroidal thickness (184 ± 78.4 vs. 287 ± 46.4 μm; P < 0.001) was significantly thinner in the OA group.
Acquisition of OCT scans in OA can be challenging. This study showed that the subfoveal retinal thickness and choroidal thickness measured across the scans were significantly different in the OA group compared to controls. In the future, more studies are required to evaluate the role of the choroid and its relationship to emmetropization in albinism.
摘要：
研究眼白化病(OA)患者增强深度成像光学相干断层扫描中视网膜和脉络膜厚度的变化，并与年龄匹配的健康受试者进行比较。
这项回顾性观察研究对24例临床诊断为OA患者的48只眼和年龄进行了观察，性别,和轴向长度匹配的对照健康受试者。所有患者均接受了详细的眼科检查和单线水平光栅增强深度成像-光学相干断层扫描（光谱，海德堡工程公司）。测量视网膜和脉络膜厚度，比较,并对两组进行了分析。两组间采用Mann-WhitneyU检验进行分析。P<0.05被认为是显著的。
OA组和对照组的平均年龄分别为28.3±11.6岁和29.9±10.6岁,分别。OA组的球形等效范围为-8.5D至+10.5D,对照组为-8.0D至+10.0D。两组之间的平均轴向长度（P=0.652）具有可比性。平均视网膜厚度(272±34.3vs.与对照组相比，OA组的213±13.8μm；P<0.001）更大。平均脉络膜厚度(184±78.4vs.287±46.4μm；P<0.001）在OA组中明显变薄。
在OA中获取OCT扫描可能具有挑战性。这项研究表明，与对照组相比，OA组的中心凹下视网膜厚度和脉络膜厚度在扫描中测量的差异显着。在未来,需要更多的研究来评估脉络膜的作用及其与白化病的关系。
这项回顾性观察研究对24例临床诊断为OA患者的48只眼和年龄进行了观察，性别,和轴向长度匹配的对照健康受试者。所有患者均接受了详细的眼科检查和单线水平光栅增强深度成像-光学相干断层扫描（光谱，海德堡工程公司）。测量视网膜和脉络膜厚度，比较,并对两组进行了分析。两组间采用Mann-WhitneyU检验进行分析。P<0.05被认为是显著的。
OA组和对照组的平均年龄分别为28.3±11.6岁和29.9±10.6岁,分别。OA组的球形等效范围为-8.5D至+10.5D,对照组为-8.0D至+10.0D。两组之间的平均轴向长度（P=0.652）具有可比性。平均视网膜厚度(272±34.3vs.与对照组相比，OA组的213±13.8μm；P<0.001）更大。平均脉络膜厚度(184±78.4vs.287±46.4μm；P<0.001）在OA组中明显变薄。
在OA中获取OCT扫描可能具有挑战性。这项研究表明，与对照组相比，OA组的中心凹下视网膜厚度和脉络膜厚度在扫描中测量的差异显着。在未来,需要更多的研究来评估脉络膜的作用及其与白化病的关系。
