Abstract：
Objective: The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carb diet. Ketone bodies increase in the blood due to low carbohydrate content and high-fat content in the diet. The most important feature of the ketogenic diet is that it causes the production of ketone bodies in the liver. Ketone bodies are an alternative fuel to glucose for the brain and form the structure necessary for the cell membrane and biosynthesis of triglycerides. The ketogenic diet provides evidence on seizure control with anticonvulsant effects. In this review, the positive/negative effects of KD on seizure control, place, importance, quality of life, cognition, and behavior in the treatment of resistant epilepsy were examined.Methods: Scientific information on the subject was obtained from the literature accessed through databases such as MEDLINE, Embase, Web of Science, Cochrane Central, www.ClinicalTrials.gov, PubMed, Science Direct, and Google Scholar.Results: Although it has started to be used as a treatment method in many diseases today, the main area of effect of KD is drug-resistant epilepsy. In order for the ketogenic diet to be successful in these patients, it is necessary to choose the appropriate patient, medical treatment and diet plan, inform the patient sufficiently, and perform frequent monitoring in accordance with the follow-up criteria. It is argued that KD is one of the most effective treatments for epilepsy.Conclusion: The fact that KDs generally have a restricted diet pattern, the need for supplementation, biochemical findings and possible side effects raise the issue of diet sustainability. More clinical studies are needed to generalize.
摘要：
■生酮饮食（KD）是一种高脂肪饮食，充足的蛋白质，和低碳水化合物饮食。由于饮食中的低碳水化合物含量和高脂肪含量，酮体在血液中增加。生酮饮食的最重要特征是它导致肝脏中酮体的产生。酮体是大脑葡萄糖的替代燃料，并形成细胞膜和甘油三酯生物合成所需的结构。生酮饮食提供了具有抗惊厥作用的癫痫发作控制的证据。在这次审查中,KD对癫痫发作控制的积极/消极影响，地点,重要性,生活质量,认知，并对难治性癫痫的治疗行为进行了检查。
■有关该主题的科学信息是从通过MEDLINE等数据库访问的文献中获得的，Embase,WebofScience,CochraneCentral,www.ClinicalTrials.gov,PubMed,科学直接，谷歌学者。
■尽管如今已开始将其用作许多疾病的治疗方法，KD的主要作用区域是耐药性癫痫。为了使这些患者的生酮饮食成功，有必要选择合适的病人，医疗和饮食计划，充分告知患者，并根据后续标准进行频繁监测。有人认为KD是癫痫最有效的治疗方法之一。
■KDs通常有限制的饮食模式，需要补充，生化发现和可能的副作用引发了饮食可持续性的问题。需要更多的临床研究来推广。
■有关该主题的科学信息是从通过MEDLINE等数据库访问的文献中获得的，Embase,WebofScience,CochraneCentral,www.ClinicalTrials.gov,PubMed,科学直接，谷歌学者。
■尽管如今已开始将其用作许多疾病的治疗方法，KD的主要作用区域是耐药性癫痫。为了使这些患者的生酮饮食成功，有必要选择合适的病人，医疗和饮食计划，充分告知患者，并根据后续标准进行频繁监测。有人认为KD是癫痫最有效的治疗方法之一。
■KDs通常有限制的饮食模式，需要补充，生化发现和可能的副作用引发了饮食可持续性的问题。需要更多的临床研究来推广。
