Abstract：
UNASSIGNED: Vibrio cholerae O1/O139 is responsible for cholera epidemics that remains a huge public health menace across the globe. Furthermore, an increasing resistance rate among V. cholerae strains has been reported around the world. Therefore, the objective of this meta-analysis was to evaluate the weighted pooled resistance (WPR) rates in clinical V. cholerae O1/O139 isolates based on different years, areas, antimicrobial susceptibility testing, and resistance rates.
UNASSIGNED: We searched the studies in PubMed, Scopus, Embase, and Web of Science (until January 2020). Statistical analyses were conducted using STATA software (ver. 14.0).
UNASSIGNED: A total of 139 studies investigating 24,062 V. cholerae O1/O139 isolates were analyzed. The majority of the studies originated in Asia (n = 102). The WPR rates were as follows: azithromycin 1%, erythromycin 36%, ciprofloxacin 3%, cotrimoxazole 79%, doxycycline 7%, and tetracycline 20%. There was increased resistance to cotrimoxazole, ciprofloxacin, and tetracycline during the 1980-2020 years.
UNASSIGNED: Temporal changes in antibiotic resistance rate found in this study demonstrated the critical continuous surveillance of antibiotic resistance. Also, ciprofloxacin, azithromycin, gentamicin, cephalexin, imipenem, ofloxacin, and norfloxacin were found to be the best antibiotics against V. cholera, with the highest and the lowest effectiveness resistance rate.
UNASSIGNED: We searched the studies in PubMed, Scopus, Embase, and Web of Science (until January 2020). Statistical analyses were conducted using STATA software (ver. 14.0).
UNASSIGNED: A total of 139 studies investigating 24,062 V. cholerae O1/O139 isolates were analyzed. The majority of the studies originated in Asia (n = 102). The WPR rates were as follows: azithromycin 1%, erythromycin 36%, ciprofloxacin 3%, cotrimoxazole 79%, doxycycline 7%, and tetracycline 20%. There was increased resistance to cotrimoxazole, ciprofloxacin, and tetracycline during the 1980-2020 years.
UNASSIGNED: Temporal changes in antibiotic resistance rate found in this study demonstrated the critical continuous surveillance of antibiotic resistance. Also, ciprofloxacin, azithromycin, gentamicin, cephalexin, imipenem, ofloxacin, and norfloxacin were found to be the best antibiotics against V. cholera, with the highest and the lowest effectiveness resistance rate.
摘要：
■霍乱弧菌O1/O139是霍乱流行的原因，仍然是全球范围内巨大的公共卫生威胁。此外，据报道，世界各地的霍乱弧菌菌株耐药率不断上升。因此,这项荟萃分析的目的是评估基于不同年份的临床霍乱弧菌O1/O139分离株的加权合并耐药率（WPR），区域,抗菌药物敏感性试验,和阻力率。
■我们搜索了PubMed中的研究，Scopus,Embase,和WebofScience（至2020年1月）。使用STATA软件（ver。14.0)。
■总共139项研究调查了24,062霍乱弧菌O1/O139分离株。大多数研究起源于亚洲（n=102）。WPR率如下：阿奇霉素1%，红霉素36%,环丙沙星3%,复方新诺明79%,强力霉素7%,和四环素20%.对复方新诺明的耐药性增加，环丙沙星,和四环素在1980-2020年。
■本研究中发现的抗生素耐药率的时间变化证明了对抗生素耐药性的关键连续监测。此外，环丙沙星,阿奇霉素,庆大霉素,头孢氨苄,亚胺培南,氧氟沙星,诺氟沙星被发现是抗霍乱弧菌的最佳抗生素，具有最高和最低的效力抵抗率。
■我们搜索了PubMed中的研究，Scopus,Embase,和WebofScience（至2020年1月）。使用STATA软件（ver。14.0)。
■总共139项研究调查了24,062霍乱弧菌O1/O139分离株。大多数研究起源于亚洲（n=102）。WPR率如下：阿奇霉素1%，红霉素36%,环丙沙星3%,复方新诺明79%,强力霉素7%,和四环素20%.对复方新诺明的耐药性增加，环丙沙星,和四环素在1980-2020年。
■本研究中发现的抗生素耐药率的时间变化证明了对抗生素耐药性的关键连续监测。此外，环丙沙星,阿奇霉素,庆大霉素,头孢氨苄,亚胺培南,氧氟沙星,诺氟沙星被发现是抗霍乱弧菌的最佳抗生素，具有最高和最低的效力抵抗率。
