关键词: ACEi, angiotensin converting enzyme inhibitor ASM, appendicular skeletal muscle mass AWGS, Asian Working Group for Sarcopenia BIA, bioelectrical impedance analysis BMI, body mass index CINV, chemotherapy-induced nausea and vomiting CT, computed tomography DXA, dual-energy x-ray absorptiometry Definition EMT, epithelial-to-mesenchymal transition EWGSOP, European Working Group on Sarcopenia in Older People GH, growth hormone HMB, β-hydroxy-β-methylbutyrate HRT, hormone replacement therapy IGF-1, insulin like growth factor-1 Intervention L3, the third lumbar vertebra MRI, magnetic resonance imaging NLR, neutrophil to lymphocyte ratio OECD, Organisation for Economic Co-operation and Development OS, overall survival the length of time from either the date of diagnosis or the start of treatment for a cancer that patients diagnosed with the disease are still alive Ovarian carcinoma PFS, progression-free survival the length of time during and after the treatment of cancer that a patient lives with the disease but it does not get worse Physiology Practice RM, repetition maximum SARM, selective androgen receptor modulator SMM, skeletal muscle mass SPPB, Short Physical Performance Battery Sarcopenia TUG, Timed-Up and Go

来  源:   DOI:10.1016/j.smhs.2020.10.001   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Sarcopenia, loss of skeletal muscle and function, is a common condition among the elderly and is known to cause adverse health outcomes and increased risk of morbidity and mortality. This progressive and generalized disorder imposes a considerable socioeconomic burden. Sarcopenia is observed commonly in cancer patients. As Asia is one of the fastest aging regions in the world, it is clear that incidences of both sarcopenia and ovarian cancer will increase together in Asian countries. Ovarian cancer patients are vulnerable to develop sarcopenia during the treatment course and progress of disease, and a considerable number of patients with ovarian cancer seems to have physical inactivity and sarcopenia already at the time of diagnosis. Therefore, management of sarcopenia should be conducted together in parallel with ovarian cancer treatment and surveillance. Thus, in this article, we will review the clinical importance of sarcopenia in the aspect of ovarian cancer. Definition of sarcopenia, diagnosis, etiology, and intervention will be also introduced.
摘要:
肌肉减少症,骨骼肌和功能的丧失,是老年人的常见病,已知会导致不良的健康结果和增加的发病率和死亡率的风险。这种进行性和广泛性的疾病给社会经济带来了相当大的负担。在癌症患者中通常观察到肌肉减少症。亚洲是世界上老龄化最快的地区之一,很明显,在亚洲国家,肌肉减少症和卵巢癌的发病率将一起增加。卵巢癌患者在治疗过程和病情进展过程中容易发生肌少症,相当多的卵巢癌患者在诊断时似乎已经缺乏体力活动和肌肉减少症。因此,肌少症的治疗应与卵巢癌的治疗和监测同时进行.因此,在这篇文章中,我们将综述肌少症在卵巢癌方面的临床重要性。肌少症的定义,诊断,病因学,并将引入干预措施。
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