PDF(Pubmed)
Abstract：
Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. Here, we optimized and compared two mouse models for the evaluation of vaccines: the Cryptosporidium tyzzeri model, which is convenient for screening large numbers of potential mixtures of immunogens, and the Cryptosporidium parvum-infected mouse pretreated with interferon gamma-neutralizing monoclonal antibody.
摘要：
十年前，隐孢子虫病被证明是低收入国家儿童腹泻病发病率和死亡率的主要原因。开发和评估免疫原和疫苗以控制这种疾病的严重障碍是缺乏充分表征的免疫能力啮齿动物模型。这里,我们优化并比较了两种用于疫苗评估的小鼠模型：隐孢子虫模型，这便于筛选大量潜在的免疫原混合物，和用干扰素γ中和单克隆抗体预处理的隐孢子虫感染小鼠。
