%0 Journal Article
%T Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis.
%A Dayao DA
%A Jaskiewcz J
%A Lee S
%A Oliveira BC
%A Sheoran A
%A Widmer G
%A Tzipori S
%J Infect Immun
%V 90
%N 7
%D 07 2022 21
%M 35735982
%F 3.609
%R 10.1128/iai.00127-22
%X Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. Here, we optimized and compared two mouse models for the evaluation of vaccines: the Cryptosporidium tyzzeri model, which is convenient for screening large numbers of potential mixtures of immunogens, and the Cryptosporidium parvum-infected mouse pretreated with interferon gamma-neutralizing monoclonal antibody.