{Reference Type}: Journal Article
{Title}: Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis.
{Author}: Dayao DA;Jaskiewcz J;Lee S;Oliveira BC;Sheoran A;Widmer G;Tzipori S;
{Journal}: Infect Immun
{Volume}: 90
{Issue}: 7
{Year}: 07 2022 21
{Factor}: 3.609
{DOI}: 10.1128/iai.00127-22
{Abstract}: Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. Here, we optimized and compared two mouse models for the evaluation of vaccines: the Cryptosporidium tyzzeri model, which is convenient for screening large numbers of potential mixtures of immunogens, and the Cryptosporidium parvum-infected mouse pretreated with interferon gamma-neutralizing monoclonal antibody.