PDF(Pubmed)
Abstract：
Although COVID-19 has captured most of the public health attention, antimicrobial resistance (AMR) has not disappeared. To prevent the escape of resistant microorganisms in animals or environmental reservoirs a \"one health approach\" is desirable. In this context of COVID-19, AMR has probably been affected by the inappropriate or over-use of antibiotics. The increased use of antimicrobials and biocides for disinfection may have enhanced the prevalence of AMR. Antibiotics have been used empirically in patients with COVID-19 to avoid or prevent bacterial coinfection or superinfections. On the other hand, the measures to prevent the transmission of COVID-19 could have reduced the risk of the emergence of multidrug-resistant microorganisms. Since we do not currently have a sterilizing vaccine against SARS-CoV-2, the virus may still multiply in the organism and new mutations may occur. As a consequence, there is a risk of the appearance of new variants. Nature-derived anti-infective agents, such as antibodies and antimicrobial peptides (AMPs), are very promising in the fight against infectious diseases, because they are less likely to develop resistance, even though further investigation is still required.
摘要：
尽管COVID-19吸引了大部分公共卫生关注，抗生素耐药性(AMR)尚未消失。为了防止抗性微生物在动物或环境水库中的逃逸，需要“一种健康方法”。在COVID-19的这种情况下，AMR可能受到抗生素不当或过度使用的影响。用于消毒的抗微生物剂和杀生物剂的使用增加可能增加了AMR的患病率。抗生素已根据经验在COVID-19患者中使用，以避免或预防细菌合并感染或重复感染。另一方面,预防COVID-19传播的措施可能降低了出现多药耐药微生物的风险.由于我们目前没有针对SARS-CoV-2的灭菌疫苗，因此该病毒仍可能在生物体中繁殖，并且可能发生新的突变。因此,存在出现新变体的风险。天然来源的抗感染药，如抗体和抗菌肽（AMP），在抗击传染病方面非常有前途，因为它们不太可能产生抗药性，尽管仍需要进一步调查。
