PDF(Pubmed)
Abstract：
Paenibacilli are gram-variable, endospore-forming bacteria that occupy various ecologic niches. These microorganisms have been known to infect humans occasionally at various anatomic sites. However, in humans, as well as in other vertebrate animals, the relationship between disease and isolation of Paenibacillus spp. remains poorly understood. We report here a case of infection in an adult Poodle dog. The animal had nodules in the lungs and multifocal osteolytic expansile bone lesions. From bone, Paenibacillus amylolyticus was recovered by culture and identified by MALDI-TOF mass spectroscopy and 16S rDNA sequencing; pyogranulomatous inflammation was observed in lung and bone specimens. The microorganism was resistant to clindamycin and imipenem. Four-month treatment with amoxicillin-clavulanate resulted in clinical resolution of disease in this dog. Nevertheless, therapy for more prolonged periods should be considered because recurrent infections can occur as a result of the transition of Paenibacillus spores to vegetative cells. Disease caused by a Paenibacillus species has not been reported previously in dogs, to our knowledge.
摘要：
Paenibacilli是克变量,内生孢子形成细菌，占据各种生态位。已知这些微生物偶尔在各种解剖部位感染人类。然而,在人类中,以及其他脊椎动物，病与菌种分离的关系.仍然知之甚少。我们在这里报告一例成年贵宾犬感染的病例。该动物肺部有结节和多灶性溶骨性骨扩张性骨病变。从骨头，通过培养回收溶淀粉芽孢杆菌，并通过MALDI-TOF质谱和16SrDNA测序进行鉴定；在肺和骨标本中观察到脓性肉芽肿性炎症。该微生物对克林霉素和亚胺培南具有抗性。用阿莫西林-克拉维酸治疗四个月导致该狗的疾病的临床消退。然而，应考虑更长时间的治疗，因为由于类芽孢杆菌孢子向营养细胞的转变，可能会发生复发性感染。以前在狗中没有报道过由类芽孢杆菌引起的疾病，我们的知识。
