PDF(Pubmed)
Abstract：
Chicken anemia virus (CAV), which has been reported in many countries, causes severe anemia and immunosuppression in chickens. In this study, a CAV strain YN04 belonging to genotype A was first identified from infected chickens in Yunnan province, China. Moreover, the animal infection experiments further confirmed that the strain YN04 is a highly pathogenic strain, which can cause 86.67% mortality in chickens in the infection group. The mean death time of infected chickens was 13.1 days post infection (dpi). CAV infection induced severe anemia with significant decrease in packed cell volume (PCV), and serious atrophy and lesion of thymus and bursa with high viral load at 14 dpi. Besides, CAV infection caused a sharp decrease in chicken body weight and immune organ indices including the ratio of thymus or bursa to body weight at 21 dpi, which displayed the potential immunosuppression state at this stage. These findings enrich the epidemiological data on CAV and may provide information for preventing its further spread in Yunnan province, China.
摘要：
鸡贫血病毒（CAV），这在许多国家都有报道，导致鸡的严重贫血和免疫抑制。在这项研究中,首先从云南省感染的鸡中鉴定出属于基因型A的CAV株YN04，中国。此外，动物感染实验进一步证实YN04菌株是高致病性菌株，可导致感染组鸡86.67%的死亡率。感染鸡的平均死亡时间为感染后13.1天(dpi)。CAV感染引起严重贫血，填充细胞体积（PCV）显着减少，14dpi时，胸腺和法氏囊严重萎缩和病变，病毒载量高。此外,CAV感染导致鸡体重和免疫器官指数急剧下降，包括21dpi时胸腺或法氏囊与体重的比率，在这个阶段显示了潜在的免疫抑制状态。这些发现丰富了CAV的流行病学数据，可能为预防其在云南省的进一步传播提供信息。中国。
