Abstract：
The life cycle of a virus involves interacting with the host cell, entry, hijacking host machinery for viral replication, evading the host\'s immune system, and releasing mature virions. However, viruses, being small in size, can only harbor a genome large enough to code for the minimal number of proteins required for the replication and maturation of the virions. As a result, many viral proteins are multifunctional machines that do not directly obey the classic structure-function paradigm. Often, such multifunctionality is rooted in intrinsic disorder that allows viral proteins to interact with various cellular factors and remain functional in the hostile environment of different cellular compartments.
This report covers the classification of flaviviruses, their proteome organization, and the prevalence of intrinsic disorder in the proteomes of different flaviviruses. Further, we have summarized the speculations made about the apparent roles of intrinsic disorder in the observed multifunctionality of flaviviral proteins.
Small sizes of viral genomes impose multifunctionality on their proteins, which is dependent on the excessive usage of intrinsic disorder. In fact, intrinsic disorder serves as a universal functional tool, weapon, and armor of viruses and clearly plays an important role in their functionality and evolution.
This report covers the classification of flaviviruses, their proteome organization, and the prevalence of intrinsic disorder in the proteomes of different flaviviruses. Further, we have summarized the speculations made about the apparent roles of intrinsic disorder in the observed multifunctionality of flaviviral proteins.
Small sizes of viral genomes impose multifunctionality on their proteins, which is dependent on the excessive usage of intrinsic disorder. In fact, intrinsic disorder serves as a universal functional tool, weapon, and armor of viruses and clearly plays an important role in their functionality and evolution.
摘要：
病毒的生命周期涉及与宿主细胞的相互作用，条目，劫持病毒复制的宿主机器，逃避宿主的免疫系统，释放成熟的病毒体.然而,病毒,尺寸小，只能拥有一个足够大的基因组来编码病毒粒子复制和成熟所需的最少数量的蛋白质。因此,许多病毒蛋白是多功能机器，不直接服从经典的结构-功能范式。通常,这种多功能性根植于内在障碍，使病毒蛋白与各种细胞因子相互作用，并在不同细胞区室的恶劣环境中保持功能。
本报告涵盖了黄病毒的分类，他们的蛋白质组组织，以及不同黄病毒蛋白质组中内在紊乱的患病率。Further,我们总结了有关内在疾病在观察到的黄病毒蛋白多功能性中的明显作用的推测。
小尺寸的病毒基因组给它们的蛋白质带来了多功能性，这取决于过度使用内在障碍。事实上,内在障碍是一种通用的功能工具，武器,和病毒的盔甲，显然在其功能和进化中起着重要作用。
本报告涵盖了黄病毒的分类，他们的蛋白质组组织，以及不同黄病毒蛋白质组中内在紊乱的患病率。Further,我们总结了有关内在疾病在观察到的黄病毒蛋白多功能性中的明显作用的推测。
小尺寸的病毒基因组给它们的蛋白质带来了多功能性，这取决于过度使用内在障碍。事实上,内在障碍是一种通用的功能工具，武器,和病毒的盔甲，显然在其功能和进化中起着重要作用。
