Abstract：
The natural aging process as well as many age-related diseases is associated with impaired metabolic adaptation and declined ability to cope with stress. As major causes of disability and morbidity during the aging process, brain disorders, including psychiatric and neurodegenerative disorders, are likely to increase across the globe in the future decades. This narrative review investigates the link among exercise and brain disorders, aging, and inflammatory biomarkers, along with the function of brain-derived neurotrophic factor. For this study, related manuscript from all databases, Google scholar, Scopus, PubMed, and ISI were assessed. Also, in the search process, the keywords of exercise, neurodegeneration, neurotrophin, mitochondrial dysfunction, and aging were used. Mitochondrial abnormality increases neuronal abnormality and brain disease during the aging process. Stress and inflammatory factors caused by lifestyle and aging also increase brain disorders. Evidences suggest that exercise, as a noninvasive treatment strategy, has antioxidant effects and can reduce neuronal lesions. Brain-derived neurotrophic factor expression following the exercise can reduce brain symptoms; however, careful consideration should be given to a number of factors affecting the results.
摘要：
自然衰老过程以及许多与年龄相关的疾病与代谢适应受损和应对压力的能力下降有关。作为衰老过程中致残和发病的主要原因,脑部疾病,包括精神病和神经退行性疾病，在未来的几十年里，全球范围内可能会增加。这篇叙述性综述调查了运动和脑部疾病之间的联系，老化，和炎症生物标志物，以及脑源性神经营养因子的功能。对于这项研究，所有数据库的相关手稿，谷歌学者，Scopus,PubMed,并对ISI进行了评估。此外，在搜索过程中，运动的关键词，神经变性,神经营养因子,线粒体功能障碍，和老化被使用。线粒体异常在衰老过程中增加神经元异常和脑疾病。生活方式和衰老引起的压力和炎症因素也会增加脑部疾病。证据表明，锻炼，作为一种非侵入性治疗策略，具有抗氧化作用，可以减少神经元损伤。运动后脑源性神经营养因子的表达可以减轻脑部症状；然而，应仔细考虑影响结果的许多因素。
