PDF(Pubmed)
Abstract：
UNASSIGNED: Oral squamous cell carcinoma (OSCC) is the most common cancerous lesion in the oral cavity. During recent years, no significant reduction in the survival rate has been observed.
UNASSIGNED: To systematically review the literature and to summarise correlations between B7 family proteins and prognosis in OSCC.
UNASSIGNED: A systematic review of the literature about B7-H1 (PD-L1) and B7-DC (PD-L2) was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-six articles published before 22 May 2020 were included in the systematic review.
UNASSIGNED: The biggest study group consisted of 305 patients and the smallest - 10 patients. PD-L1 proved to be a prognostic factor in patients with OSCC. Immunohistochemistry was the most commonly used diagnostic method.
UNASSIGNED: Any mutations in the gene encoding PD-L1 and quantitative or functional changes in the status of PD-L1 may be important in the prognosis of OSCC.
UNASSIGNED: To systematically review the literature and to summarise correlations between B7 family proteins and prognosis in OSCC.
UNASSIGNED: A systematic review of the literature about B7-H1 (PD-L1) and B7-DC (PD-L2) was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-six articles published before 22 May 2020 were included in the systematic review.
UNASSIGNED: The biggest study group consisted of 305 patients and the smallest - 10 patients. PD-L1 proved to be a prognostic factor in patients with OSCC. Immunohistochemistry was the most commonly used diagnostic method.
UNASSIGNED: Any mutations in the gene encoding PD-L1 and quantitative or functional changes in the status of PD-L1 may be important in the prognosis of OSCC.
摘要：
■口腔鳞状细胞癌（OSCC）是口腔中最常见的癌变。近年来,没有观察到存活率的显著降低。
■系统回顾文献，总结B7家族蛋白与OSCC预后的相关性。
■对有关B7-H1（PD-L1）和B7-DC（PD-L2）的文献进行了系统回顾，遵循系统审查和荟萃分析(PRISMA)指南的首选报告项目。在2020年5月22日之前发表的36篇文章被纳入系统评价。
■最大的研究组由305名患者和最小的10名患者组成。PD-L1被证明是OSCC患者的预后因素。免疫组织化学是最常用的诊断方法。
■编码PD-L1的基因中的任何突变以及PD-L1状态的数量或功能变化可能对OSCC的预后很重要。
■系统回顾文献，总结B7家族蛋白与OSCC预后的相关性。
■对有关B7-H1（PD-L1）和B7-DC（PD-L2）的文献进行了系统回顾，遵循系统审查和荟萃分析(PRISMA)指南的首选报告项目。在2020年5月22日之前发表的36篇文章被纳入系统评价。
■最大的研究组由305名患者和最小的10名患者组成。PD-L1被证明是OSCC患者的预后因素。免疫组织化学是最常用的诊断方法。
■编码PD-L1的基因中的任何突变以及PD-L1状态的数量或功能变化可能对OSCC的预后很重要。
