%0 Journal Article
%T The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2).
%A Starzyńska A
%A Sejda A
%A Adamski Ł
%A Adamska P
%A Pęksa R
%A Sakowicz-Burkiewicz M
%A Wychowański P
%A Jereczek-Fossa BA
%J Postepy Dermatol Alergol
%V 39
%N 2
%D Apr 2022
%M 35645666
%F 1.664
%R 10.5114/ada.2020.98522
%X <B>UNASSIGNED: </B>Oral squamous cell carcinoma (OSCC) is the most common cancerous lesion in the oral cavity. During recent years, no significant reduction in the survival rate has been observed.<BR><B>UNASSIGNED: </B>To systematically review the literature and to summarise correlations between B7 family proteins and prognosis in OSCC.<BR><B>UNASSIGNED: </B>A systematic review of the literature about B7-H1 (PD-L1) and B7-DC (PD-L2) was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-six articles published before 22 May 2020 were included in the systematic review.<BR><B>UNASSIGNED: </B>The biggest study group consisted of 305 patients and the smallest - 10 patients. PD-L1 proved to be a prognostic factor in patients with OSCC. Immunohistochemistry was the most commonly used diagnostic method.<BR><B>UNASSIGNED: </B>Any mutations in the gene encoding PD-L1 and quantitative or functional changes in the status of PD-L1 may be important in the prognosis of OSCC.