PDF(Pubmed)
Abstract：
We aimed to evaluate if dietary supplementation with a nutraceutical compound (Eufortyn® Colesterolo Plus) containing standardized bergamot polyphenolic fraction phytosome (Vazguard®), artichoke extract (Pycrinil®), artichoke dry extract. (Cynara scolymus L.), Q10 phytosome(Ubiqosome®) and zinc, could positively affect serum lipids concentration, systemic inflammation and indexes of non-alcoholic fatty liver disease (NAFLD) in 60 healthy subjects with polygenic hypercholesterolemia. Participants were adhering to a low-fat, low-sodium Mediterranean diet for a month before being randomly allocated to 8-week treatment with 1 pill each day of either Eufortyn® Colesterolo Plus or placebo. Dietary supplementation with Eufortyn® Colesterolo Plus was associated with significant improvement in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), high-sensitivity C-reactive protein (hs-CRP) and endothelial reactivity (ER) in comparison with baseline, and with significant reductions in waist circumference, TC, LDL-C, LDL-C/HDL-C, lipid accumulation product and fatty liver index compared to placebo. The study shows that dietary supplementation with standardized bergamot polyphenolic fraction phytosome, artichoke extracts, Q10 phytosome and zinc safely exerts significant improvements in serum lipids, systemic inflammation, indexes of NAFLD and endothelial reactivity in healthy subjects with moderate hypercholesterolemia.
摘要：
我们的目的是评估膳食补充剂是否含有标准化佛手瓜多酚部分植物体（Vazguard®）的营养化合物（Eufortyn®ColesteroloPlus），朝鲜蓟提取物（Pycrinil®），朝鲜蓟干提取物。（CynarascolymusL.），Q10植物体（Ubiqosome®）和锌，可以积极影响血清脂质浓度，60例多基因性高胆固醇血症健康受试者的全身炎症和非酒精性脂肪性肝病（NAFLD）指标。参与者坚持低脂肪，低钠地中海饮食一个月，然后随机分配给8周治疗，每天服用1片Eufortyn®ColesteroloPlus或安慰剂。饮食补充Eufortyn®ColesteroloPlus与总胆固醇（TC）的显着改善有关，低密度脂蛋白胆固醇（LDL-C），非高密度脂蛋白胆固醇（非HDL-C），与基线相比，高敏C反应蛋白（hs-CRP）和内皮反应性（ER），腰围显著减少，TC,LDL-C,LDL-C/HDL-C,与安慰剂相比，脂质积累产物和脂肪肝指数。研究表明，在饮食中添加标准化佛手多酚部分植物体，朝鲜蓟提取物,Q10植物体和锌安全地发挥血清脂质的显着改善，全身性炎症,中度高胆固醇血症健康受试者的NAFLD和内皮反应性指标。
