Abstract：
This systematic review and meta-analysis was performed to assess the effects of Sn-2-palmitate-enriched formula feeding on infants\' growth, stool characteristics, stool fatty acid (FA) soap contents and bone mineral content (BMC). We searched PubMed, MEDLINE, Embase and Web of Science for randomized controlled trials published up to April 2022. Sixteen studies involving 1,931 infants were included. From each included study, weighted mean differences (WMDs) and 95% confidence intervals (CIs) for each of the above mentioned outcomes were extracted and pooled with a fixed-effects model (I2 ≤ 50%) or a random-effects model (I2 > 50%). Infants fed Sn-2-palmitate-enriched formula exhibited greater weight gains (WMD: 0.81; 95% CI: 0.23, 1.39 g/d; I2 = 0.00%), lower contents of total stool FA soaps (WMD: -3.47; 95% CI: -5.08, -1.86 mg/100 mg; I2 = 0.00%) and higher BMC (WMD: 7.08; 95% CI: 4.05, 10.10; I2 = 0.00%) than infants fed standard formula. However, no difference was observed in these outcomes between infants fed Sn-2-palmitate-enriched formula and those fed human milk. This meta-analysis demonstrated that compared with standard formula feeding, Sn-2-palmitate-enriched formula feeding could effectively promote weight gains, bone mineral accumulation and stool FA soap reduction in infants.
摘要：
本系统综述和荟萃分析旨在评估富含Sn-2-棕榈酸酯的配方喂养对婴儿生长的影响。大便特点,粪便脂肪酸（FA）皂含量和骨矿物质含量（BMC）。我们搜索了PubMed,MEDLINE,Embase和WebofScience的随机对照试验发表至2022年4月。包括16项研究，涉及1,931名婴儿。从每一项纳入的研究中，提取上述各结局的加权平均差(WMD)和95%置信区间(CIs),并与固定效应模型(I2≤50%)或随机效应模型(I2>50%)合并.饲喂富含Sn-2-棕榈酸酯配方的婴儿表现出更大的体重增加(WMD:0.81;95%CI:0.23,1.39g/d;I2=0.00%),与标准配方奶粉喂养的婴儿相比,粪便总脂肪酸皂含量较低(WMD:-3.47;95%CI:-5.08,-1.86mg/100mg;I2=0.00%),BMC含量较高(WMD:7.08;95%CI:4.05,10.10;I2=0.00%)。然而,在这些结局中,饲喂富含棕榈酸Sn-2的配方奶粉的婴儿和饲喂人乳的婴儿之间没有观察到差异.这项荟萃分析表明，与标准配方喂养相比，富含Sn-2-棕榈酸的配方饲料能有效促进增重,婴儿骨矿物质积累和粪便FA肥皂减少。
