Abstract：
OBJECTIVE: We aimed to investigate the use of core needle biopsy (CNB) in epididymal tuberculosis (TB) diagnosis.
METHODS: We analyzed 41 samples collected between January 1, 2018, and January 31, 2021, from patients who underwent CNB for suspected epididymal TB. All specimens were examined using histopathological examination and the Xpert Mycobacterium tuberculosis bacilli/rifampicin (MTB/RIF) assay. We analyzed the examination results to determine the application value of CNB in epididymal TB diagnosis and evaluate its safety.
RESULTS: According to the comprehensive reference standard established in this study, 37 of the 41 patients had epididymal TB and four patients had chronic epididymitis. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of histopathological examination were 86.49% (71.23-95.46%), 100.00% (39.76-100.00%), 100.00% (89.11-100.00%), 44.44% (13.70-78.80%), and 0.93 (0.81-0.99), respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of the Xpert MTB/RIF assay were 62.16% (44.76-77.54%), 100.00% (39.76-100.00%), 100.00% (85.18-100.00%), 22.22% (6.41-47.76%), and 0.81 (0.66-0.92), respectively. No postoperative complication attained a Clavien-Dindo classification grade of >2.
CONCLUSIONS: CNB was useful in diagnosing epididymal TB. Therefore, we recommend using CNB as a sample collection tool for diagnosing epididymal TB.
METHODS: We analyzed 41 samples collected between January 1, 2018, and January 31, 2021, from patients who underwent CNB for suspected epididymal TB. All specimens were examined using histopathological examination and the Xpert Mycobacterium tuberculosis bacilli/rifampicin (MTB/RIF) assay. We analyzed the examination results to determine the application value of CNB in epididymal TB diagnosis and evaluate its safety.
RESULTS: According to the comprehensive reference standard established in this study, 37 of the 41 patients had epididymal TB and four patients had chronic epididymitis. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of histopathological examination were 86.49% (71.23-95.46%), 100.00% (39.76-100.00%), 100.00% (89.11-100.00%), 44.44% (13.70-78.80%), and 0.93 (0.81-0.99), respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of the Xpert MTB/RIF assay were 62.16% (44.76-77.54%), 100.00% (39.76-100.00%), 100.00% (85.18-100.00%), 22.22% (6.41-47.76%), and 0.81 (0.66-0.92), respectively. No postoperative complication attained a Clavien-Dindo classification grade of >2.
CONCLUSIONS: CNB was useful in diagnosing epididymal TB. Therefore, we recommend using CNB as a sample collection tool for diagnosing epididymal TB.
摘要：
目的：我们旨在探讨芯针活检（CNB）在附睾结核（TB）诊断中的应用。
方法：我们分析了在2018年1月1日至2021年1月31日之间收集的41例样本，这些样本来自因疑似附睾TB而接受CNB的患者。使用组织病理学检查和Xpert结核分枝杆菌/利福平（MTB/RIF）测定法检查所有标本。对检查结果进行分析,确定CNB在附睾结核诊断中的应用价值,并评价其安全性。
结果：根据本研究中建立的综合参考标准，41例患者中有37例患有附睾TB，4例患有慢性附睾炎。敏感性,特异性，正预测值，负预测值，组织病理学检查曲线下面积为86.49%(71.23-95.46%),100.00%（39.76-100.00%），100.00%（89.11-100.00%），44.44%（13.70-78.80%），和0.93（0.81-0.99），分别。敏感性,特异性，正预测值，负预测值，XpertMTB/RIF曲线下面积为62.16%(44.76-77.54%),100.00%（39.76-100.00%），100.00%（85.18-100.00%），22.22%（6.41-47.76%），和0.81（0.66-0.92），分别。术后并发症未达到Clavien-Dindo分类等级>2。
结论：CNB对诊断附睾结核有帮助。因此,我们建议使用CNB作为诊断附睾TB的样本收集工具.
方法：我们分析了在2018年1月1日至2021年1月31日之间收集的41例样本，这些样本来自因疑似附睾TB而接受CNB的患者。使用组织病理学检查和Xpert结核分枝杆菌/利福平（MTB/RIF）测定法检查所有标本。对检查结果进行分析,确定CNB在附睾结核诊断中的应用价值,并评价其安全性。
结果：根据本研究中建立的综合参考标准，41例患者中有37例患有附睾TB，4例患有慢性附睾炎。敏感性,特异性，正预测值，负预测值，组织病理学检查曲线下面积为86.49%(71.23-95.46%),100.00%（39.76-100.00%），100.00%（89.11-100.00%），44.44%（13.70-78.80%），和0.93（0.81-0.99），分别。敏感性,特异性，正预测值，负预测值，XpertMTB/RIF曲线下面积为62.16%(44.76-77.54%),100.00%（39.76-100.00%），100.00%（85.18-100.00%），22.22%（6.41-47.76%），和0.81（0.66-0.92），分别。术后并发症未达到Clavien-Dindo分类等级>2。
结论：CNB对诊断附睾结核有帮助。因此,我们建议使用CNB作为诊断附睾TB的样本收集工具.
