PDF(Pubmed)
Abstract：
Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as important regulators of the immune system and are involved in the control of immune cell biology, disease pathogenesis, as well as vaccine responses. A repository of ncRNA-immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune disorders. Here, we describe a comprehensive database, RNA2Immune, which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function, immune disease, cancer immunology, and vaccines. The current version of RNA2Immune documents 50,433 immune-ncRNA associations in 42 host species, including (1) 6690 ncRNA associations with immune functions involving 31 immune cell types; (2) 38,672 ncRNA associations with 348 immune diseases; (3) 4833 ncRNA associations with cancer immunology; and (4) 238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 diseases. RNA2Immune provides a user-friendly interface for browsing, searching, and downloading ncRNA-immune system associations. Collectively, RNA2Immune provides important information about how ncRNAs influence immune cell function, how dysregulation of these ncRNAs leads to pathological consequences (immune diseases and cancers), and how ncRNAs affect immune responses to vaccines. RNA2Immune is available at http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp.
摘要：
非编码RNA（ncRNAs），如microRNAs（miRNAs），长链非编码RNA（lncRNA），和环状RNAs(circRNAs)，已经成为免疫系统的重要调节剂，并参与免疫细胞生物学的控制，疾病的发病机理，以及疫苗反应。ncRNA-免疫关联的存储库将促进我们对免疫系统中ncRNA依赖性机制的理解，并促进免疫疾病的治疗和预防的发展。这里,我们描述了一个全面的数据库，RNA2免疫，它旨在提供实验支持的数据库的高质量资源，将ncRNA调控机制与免疫细胞功能联系起来，免疫性疾病，癌症免疫学，和疫苗。当前版本的RNA2Immune文件在42个宿主物种中的50,433个免疫-ncRNA关联，包括：（1）6690ncRNA与涉及31种免疫细胞类型的免疫功能相关；（2）38,672ncRNA与348种免疫疾病相关；（3）4833ncRNA与癌症免疫学相关；（4）238ncRNA与涉及26种针对22种疾病的疫苗反应相关。RNA2Immune提供了一个用户友好的浏览界面，搜索,并下载ncRNA-免疫系统关联。总的来说，RNA2Immune提供了有关ncRNAs如何影响免疫细胞功能的重要信息，这些ncRNAs的失调如何导致病理后果（免疫疾病和癌症），以及ncRNAs如何影响对疫苗的免疫反应。RNA2Immune可在http://bio-bigdata上获得。hrbmu.edu.cn/rna2immune/home.jsp.
