通过持续释放 SIRT - 1 激动剂以促进骨质疏松状态下的骨愈合来逆转骨稳态的失衡。
关键词: ALP, Alkaline phosphatase BMM, Bone marrow-derived macrophage BMSCs, Bone marrow-derived mesenchymal stem cells CCK-8, Cell Counting Kit-8 FBS, Fetal bovine serum FTIR, Fourier transform infrared IF, Immunofluorescence Mineral coating OPN, Osteopontin OVX, Ovariectomy Osteoblast Osteoclast Osteoporosis P1NP, Pro-collagen type 1N-terminal peptide RT-qPCR, Quantitative real-time polymerase chain reaction SBF, Simulated body fluid SEM, Scanning electron microscopy SIRT1 WB, Western blot XRD, X-ray diffraction micro-CT, Microcomputed tomography siRNA, Small interfering RNA
来 源:
DOI:10.1016/j.bioactmat.2022.04.017
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