Abstract：
A randomized crossover study in eight patients (6 F, age 57 ± 13) with overlapping GERD-IBS (non-constipation) was conducted to evaluate the effects of rice noodle vs. wheat noodle meals for breakfast and lunch on postprandial TLESR, intestinal gas production, and GERD/GI symptoms. Results: Wheat ingestion was significantly associated with more frequent TLESR after lunch than rice (5.0 ± 0.7 vs. 1.9 ± 0.3 times/2 h, p = 0.01). After lunch, wheat ingestion was significantly associated with higher H2 and CH4 levels compared to rice ingestion (p < 0.05), while H2 and CH4 levels before lunch were similar (p > 0.05). The area under curve of H2 concentration until 2 h after lunch significantly correlated with the TLESR number (r = 0.69, p = 0.04). Postprandial regurgitation (2.9 ± 1.2 vs. 0.4 ± 0.2), bloating (7.0 ± 0.4 vs. 3.1 ± 0.9), satiety (7.7 ± 0.4 vs. 3.5 ± 0.9), and belching (3.8 ± 1.2 vs. 1.1 ± 0.6) symptom scores were significantly greater after wheat compared to rice noodle ingestion (p < 0.05). Conclusion: Wheat noodle meals, part of a high FODMAP diet, induced a higher frequency of TLESRs, a higher GERD, and higher upper-GI symptom scores than rice noodle meals, part of a low FODMAP diet, in patients with overlapping IBS-GERD. These effects were associated with more intestinal gas production. Thus, a low FODMAP diet may relieve GERD symptoms in GERD patients with overlapping IBS.
摘要：
一项针对8例患者的随机交叉研究(6F，年龄57±13）与重叠GERD-IBS（非便秘）进行，以评估米粉与餐后TLESR早餐和午餐的小麦面条餐，肠道产气,和GERD/GI症状。结果：与大米相比，午餐后摄入小麦与更频繁的TLESR显着相关（5.0±0.7vs.1.9±0.3次/2小时,p=0.01)。午饭后,与水稻摄食相比，小麦摄食与较高的H2和CH4水平显着相关（p<0.05），而午餐前H2和CH4水平相似(p>0.05)。直到午餐后2小时的H2浓度曲线下面积与TLESR数显着相关（r=0.69，p=0.04）。餐后反流（2.9±1.2vs.0.4±0.2),腹胀（7.0±0.4与3.1±0.9),饱腹感(7.7±0.4vs.3.5±0.9),打气(3.8±1.2vs.与米粉摄入后相比，小麦摄入后1.1±0.6）症状评分明显更高（p<0.05）。结论：小麦面餐，高FODMAP饮食的一部分，诱导了更高的TLESR频率，更高的GERD,上消化道症状评分高于米粉，低FODMAP饮食的一部分，IBS-GERD重叠患者。这些影响与更多的肠道气体产生有关。因此，低FODMAP饮食可以缓解合并IBS的GERD患者的GERD症状.
