Patients were randomly assigned to the control group (0.75% ropivacaine) or PF-72 group (PF-72 mixed with 0.75% ropivacaine). Before surgical incision closure, 0.75% ropivacaine or PF-72 mixed with 0.75% ropivacaine was injected into the subcutaneous fat and muscle of all incisions. Postoperative pain was evaluated by the Numerical Rating Scale (NRS, 0 = no pain, 10 = most severe pain) for wound pain at 3, 6, 24, 48, and 72 h after the end of surgery.
Ninety-nine patients (control, n = 51; PF-72, n = 48) were included in the analysis. The areas under the curve of NRS for wound pain until 72 h in the control group and the PF-72 group were 188.7 ± 46.1 and 135.3 ± 49.9 h, respectively (P < 0.001). The frequency of the administration of rescue analgesics in the general ward was similar between the two groups.
PF-72 mixed with 0.75% ropivacaine reduced postoperative pain until 72 h in patients undergoing laparoscopic surgery. Although the study population was not large enough for safety evaluation, no adverse events associated with PF-72 were observed.
患者随机分为对照组(0.75%罗哌卡因)或PF-72组(PF-72与0.75%罗哌卡因混合)。手术切口闭合前,将0.75%罗哌卡因或与0.75%罗哌卡因混合的PF-72注射到所有切口的皮下脂肪和肌肉中。术后疼痛通过数值评定量表(NRS,0=没有疼痛,10=最严重的疼痛),用于手术结束后3、6、24、48和72h的伤口疼痛。
九十九名患者(对照,n=51;PF-72,n=48)包括在分析中。对照组和PF-72组直到72h的伤口疼痛NRS曲线下面积分别为188.7±46.1和135.3±49.9h,分别(P<0.001)。两组在普通病房中使用抢救镇痛药的频率相似。
在接受腹腔镜手术的患者中,PF-72与0.75%罗哌卡因混合可减轻术后疼痛直至72h。尽管研究人群不足以进行安全性评估,未观察到与PF-72相关的不良事件.