UNASSIGNED: In this retrospective multi-center study involving three pediatric laboratories, 150 healthy children and adolescents (mean age of 10.6 ± 4.5, 91 males) were enrolled. A complete echocardiographic examination has been performed, including global longitudinal strain (GLS) assessment. The following parameters of non-invasive MW have been obtained through a dedicated software: global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE), using left ventricular (LV) strain loops and non-invasive brachial artery cuff pressure values. The lowest expected values were for GWI 1,723 mmHg% in males and 1,682 mmHg% in females, for GCW 2,089 and 2,106 mmHg%, for GWE 95.9 and 95.5% whereas the highest expected value for GWW was 78 mmHg% in men and 90 mmHg% in women. The univariable and multivariable analysis showed significant associations between either GWI or GCW with SBP (β coefficient = 0.446, p < 0.001; β coefficient = 0.456, p < 0.001, respectively) and LV GLS (β coefficient = -0.268, p = 0.001; β coefficient = -0.233, p = 0.003, respectively). Inter- and intra-observer variability showed good reproducibility of non-invasive MW parameters.
UNASSIGNED: Non-invasive MW parameters were feasible and reliable in the pediatric population. This study provided normal reference ranges of these useful echocardiographic indices.
UNASSIGNED:在这项涉及三个儿科实验室的多中心回顾性研究中,纳入150名健康儿童和青少年(平均年龄10.6±4.5,男性91)。进行了完整的超声心动图检查,包括全球纵向应变(GLS)评估。通过专用软件获得了非侵入性MW的以下参数:全球工作指数(GWI),全球建设性工作(GCW),全球工作废物(GWW),和全球工作效率(GWE),使用左心室(LV)应变环和无创肱动脉袖压值。最低预期值是男性GWI1,723mmHg%,女性为1,682mmHg%,对于GCW2,089和2,106mmHg,GWE的95.9和95.5%,而GWW的最高预期值男性为78mmHg%,女性为90mmHg%。单变量和多变量分析表明GWI或GCW与SBP(β系数=0.446,p<0.001;β系数=0.456,p<0.001)和LVGLS(β系数=-0.268,p=0.001;β系数=-0.233,p=0.003)之间存在显着关联。观察者之间和观察者内部的变异性显示出非侵入性MW参数的良好可重复性。
UNASSIGNED:非侵入性MW参数在儿科人群中是可行且可靠的。这项研究提供了这些有用的超声心动图指标的正常参考范围。